Barbara Beatriz Philippi Martins
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Barbara Beatriz Philippi Martins has a total of 5 co-authors. Here are the top co-authors by number of shared publications:
- Adair Roberto Soares Santos
Post-Graduate Program in Neuroscience, Center of Biological Sciences, Federal University of Santa Catarina, Florianopolis 88040-535, SC, Brazil
2 shared publications - Dayanne da Silva Borges
Postgraduate Program in Nutrition, Federal University of Santa Catarina, Florianópolis, Brazil
2 shared publications - Erasmo Benicio Santos de Moraes Trindade
Universidade Federal de Santa Catarina, Brasil
2 shared publications - Ricardo Fernandes
Faculty of Health Sciences, Federal University of Grande Dourados, Dourados 79804-970, MS, Brazil
2 shared publications - Scheila Iria Kraus
Post-Graduate Program in Neuroscience, Center of Biological Sciences, Federal University of Santa Catarina, Florianopolis 88040-535, SC, Brazil
2 shared publications
Latest Publications
- Open Access
Gut Modulators Alter BDNF/Cortisol Axis in Severe Obesity: Additional Secondary Outcomes from a Triple-Blind Randomized Trial
The role of the gut–brain axis is crucial in maintaining homeostasis and regulating neural, hormonal, and immunological activity. This study aimed to evaluate the effects of prebiotics or synbiotics on serum markers related to emotional disorders in individuals with morbid obesity in a triple-blind, randomized trial. The sample consisted of 22 subjects (16 women and 6 men) with a mean age of 41.8 ± 8.5 years and a mean BMI of 47.7 ± 6.8 kg/m2. Serum BDNF concentrations decreased significantly after 30 days of prebiotic supplementation (p = 0.017). Serum cortisol concentrations increased in all groups between the evaluated time points, with the increase being statistically significant in the synbiotic-supplemented group (p = 0.028). Serum TNF-α concentrations increased significantly after 30 days of prebiotic supplementation when compared to the group’s baseline (p = 0.035); however, this variation did not produce a significant difference between the groups evaluated after 30 days of supplementation. The results suggest that a chronic, low-grade inflammatory state may be related to the neuroendocrine changes present in emotional disorders, but the absence of significant results in the primary outcomes is possibly due to severe underpowering. Findings from additional secondary outcomes are hypothesis-generating only, requiring confirmation in adequately powered trials.
Open AccessGut Modulators Alter BDNF/Cortisol Axis in Severe Obesity: Additional Secondary Outcomes from a Triple-Blind Randomized Trial
The role of the gut–brain axis is crucial in maintaining homeostasis and regulating neural, hormonal, and immunological activity. This study aimed to evaluate the effects of prebiotics or synbiotics on serum markers related to emotional disorders in individuals with morbid obesity in a triple-blind, randomized trial. The sample consisted of 22 subjects (16 women and 6 men) with a mean age of 41.8 ± 8.5 years and a mean BMI of 47.7 ± 6.8 kg/m2. Serum BDNF concentrations decreased significantly after 30 days of prebiotic supplementation (p = 0.017). Serum cortisol concentrations increased in all groups between the evaluated time points, with the increase being statistically significant in the synbiotic-supplemented group (p = 0.028). Serum TNF-α concentrations increased significantly after 30 days of prebiotic supplementation when compared to the group’s baseline (p = 0.035); however, this variation did not produce a significant difference between the groups evaluated after 30 days of supplementation. The results suggest that a chronic, low-grade inflammatory state may be related to the neuroendocrine changes present in emotional disorders, but the absence of significant results in the primary outcomes is possibly due to severe underpowering. Findings from additional secondary outcomes are hypothesis-generating only, requiring confirmation in adequately powered trials.
- Open Access
- 24 April 2026
- Published by MDPI AG in Preprints.org
Gut Modulators Alter BDNF/Cortisol Axis in Severe Obesity: A Triple-Blind Randomized Trial
The role of the gut-brain axis is crucial in maintaining homeostasis and regulating neural, hormonal, and immunological activity. This study aimed to evaluate the effects of prebiotic or synbiotic on serum markers related to emotional disorders in individuals with morbid obesity in a triple-blind randomized trial. The sample consisted of 22 subjects, 16 women and 6 men, with a mean age of 41.8 ± 8.5 years and a mean BMI of 47.7 ± 6.8 kg/m2. Serum BDNF concentrations decreased significantly after 30 days of prebiotic supplementation (p=0.017), and when analyzing the difference between the evaluated moments, only this group showed a reduction in this parameter. Serum cortisol concentrations were increased in all groups between the moments evaluated, being statistically significant in the synbiotic supplemented group (p=0.028). Serum TNF-α concentrations increased significantly after 30 days of prebiotic supplementation when compared to the baseline of the group itself (p=0.035): however, this variation did not promote significant difference between the groups evaluated after 30 days of supplementation. The results suggest that low grade chronic inflammatory state may be related to neuroendocrine changes present in emotional disorders, but studies with greater sampling power and correlations with clinical findings are necessary to strengthen this evidence.
- 24 April 2026
- Published by MDPI AG in Preprints.org
Open AccessGut Modulators Alter BDNF/Cortisol Axis in Severe Obesity: A Triple-Blind Randomized Trial
The role of the gut-brain axis is crucial in maintaining homeostasis and regulating neural, hormonal, and immunological activity. This study aimed to evaluate the effects of prebiotic or synbiotic on serum markers related to emotional disorders in individuals with morbid obesity in a triple-blind randomized trial. The sample consisted of 22 subjects, 16 women and 6 men, with a mean age of 41.8 ± 8.5 years and a mean BMI of 47.7 ± 6.8 kg/m2. Serum BDNF concentrations decreased significantly after 30 days of prebiotic supplementation (p=0.017), and when analyzing the difference between the evaluated moments, only this group showed a reduction in this parameter. Serum cortisol concentrations were increased in all groups between the moments evaluated, being statistically significant in the synbiotic supplemented group (p=0.028). Serum TNF-α concentrations increased significantly after 30 days of prebiotic supplementation when compared to the baseline of the group itself (p=0.035): however, this variation did not promote significant difference between the groups evaluated after 30 days of supplementation. The results suggest that low grade chronic inflammatory state may be related to neuroendocrine changes present in emotional disorders, but studies with greater sampling power and correlations with clinical findings are necessary to strengthen this evidence.