Danielle Henn
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Danielle Henn has a total of 11 co-authors. Here are the top co-authors by number of shared publications:
Aleksander Wielenga
Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, USA
1 shared publication- Bala Bharathi Burugula
Department of Human Genetics, University of Michigan Medical School, Ann Arbor, USA
1 shared publication - Gonçalo Vale
Center for Human Nutrition, University of Texas Southwestern Medical Center
1 shared publication - Jacob Otto Kitzman
Department of Human Genetics, University of Michigan Medical School, Ann Arbor, USA
1 shared publication - Jeffrey G. McDonald
Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, USA
1 shared publication Jiaxuan Liang
Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, USA
1 shared publication
Latest Publications
- Open Access
- 2 May 2026
- Published by Springer Nature in The EMBO Journal
- Vol. 45 (11) , 3699-3730
Peroxisome-derived ether lipids regulate lysosomal exocytosis
Lysosomes and peroxisomes are essential for cellular homeostasis, yet how their activities are coordinated remains poorly understood. Here, we identify peroxisome-derived ether lipids as key regulators of lysosomal function. A genome-wide CRISPR/Cas9 screen in LYSET-deficient mucolipidosis V cells revealed that disruption of ether lipid synthesis genes or peroxins markedly reduces lysosome accumulation and restores degradative capacity. Genetic or pharmacological inhibition of ether lipid synthesis enhanced lysosomal exocytosis and promoted the clearance of undigested material independently of mannose-6-phosphate trafficking. Conversely, supplementation with the ether lipid precursor hexadecylglycerol increased lysosome abundance, while reducing their degradative capacity. These findings uncover a peroxisome-lysosome metabolic axis, in which ether lipids act as bidirectional regulators of lysosomal number and function independently of the lysosomal master regulator TFEB. Our findings reveal how peroxisome-localized lipid metabolism modulates lysosomal homeostasis, and suggest potential new strategies to combat lysosomal and peroxisomal disorders.
- 2 May 2026
- Published by Springer Nature in The EMBO Journal
- Vol. 45 (11) , 3699-3730
Open AccessPeroxisome-derived ether lipids regulate lysosomal exocytosis
Lysosomes and peroxisomes are essential for cellular homeostasis, yet how their activities are coordinated remains poorly understood. Here, we identify peroxisome-derived ether lipids as key regulators of lysosomal function. A genome-wide CRISPR/Cas9 screen in LYSET-deficient mucolipidosis V cells revealed that disruption of ether lipid synthesis genes or peroxins markedly reduces lysosome accumulation and restores degradative capacity. Genetic or pharmacological inhibition of ether lipid synthesis enhanced lysosomal exocytosis and promoted the clearance of undigested material independently of mannose-6-phosphate trafficking. Conversely, supplementation with the ether lipid precursor hexadecylglycerol increased lysosome abundance, while reducing their degradative capacity. These findings uncover a peroxisome-lysosome metabolic axis, in which ether lipids act as bidirectional regulators of lysosomal number and function independently of the lysosomal master regulator TFEB. Our findings reveal how peroxisome-localized lipid metabolism modulates lysosomal homeostasis, and suggest potential new strategies to combat lysosomal and peroxisomal disorders.