Kris Killmann
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Kris Killmann has a total of 7 co-authors. Here are the top co-authors by number of shared publications:
- Christian Ebner
Institute for Biology, Humboldt University of Berlin, Berlin, Germany
1 shared publication - Dieter Jaeger
Emory University
1 shared publication - Eduardo Maristany de Las Casas
Institute for Biology, Humboldt University of Berlin, Berlin, Germany
1 shared publication - Lukas Münster
Zentrum für molekulare Neurobiologie, UKE Hamburg, Hamburg, Germany
1 shared publication - Matthew Evan Larkum
Institute for Biology, Humboldt University of Berlin, Berlin, Germany
1 shared publication - Moritz Drüke
Institute for Biology, Humboldt University of Berlin, Berlin, Germany
1 shared publication
Latest Publications
- Top Cited Papers
- 7 May 2026
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 392 (6798) , eadx4358
Tuft dendrites in frontal motor cortex enable flexible learning
Flexible learning relies on integrating sensory and contextual information to adjust behavioral output in different environments. The anterolateral motor cortex (ALM) is a frontal area critical for action selection in rodents. We found that inputs critical to decision-making converge on the apical tuft dendrites of layer 5b pyramidal neurons in ALM. We therefore investigated the role of these dendrites in a rule-switching paradigm. Activation of dendrite-inhibiting layer 1 interneurons impaired relearning, without affecting previously learned behavior. This inhibition profoundly suppressed global calcium activity in dendritic shafts but not local transients in spines, while additionally reducing burst firing. Moreover, excitatory synaptic inputs to tuft dendrites exhibited rule-dependent clustering. We conclude that dendritic calcium signaling is a key computational component of flexible learning.
- 7 May 2026
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 392 (6798) , eadx4358
Top Cited PapersTuft dendrites in frontal motor cortex enable flexible learning
Flexible learning relies on integrating sensory and contextual information to adjust behavioral output in different environments. The anterolateral motor cortex (ALM) is a frontal area critical for action selection in rodents. We found that inputs critical to decision-making converge on the apical tuft dendrites of layer 5b pyramidal neurons in ALM. We therefore investigated the role of these dendrites in a rule-switching paradigm. Activation of dendrite-inhibiting layer 1 interneurons impaired relearning, without affecting previously learned behavior. This inhibition profoundly suppressed global calcium activity in dendritic shafts but not local transients in spines, while additionally reducing burst firing. Moreover, excitatory synaptic inputs to tuft dendrites exhibited rule-dependent clustering. We conclude that dendritic calcium signaling is a key computational component of flexible learning.