Sebastián Muñoz-Farias
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Sebastián Muñoz-Farias has a total of 6 co-authors. Here are the top co-authors by number of shared publications:
- Alan Raul Cabrera
Departamento de Química Inorgánica, Escuela de Química, Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, Vicuña Mackenna 4860, Macul, Santiago 7820436, Chile
1 shared publication - Alondra Villegas-Menares
Departamento de Química Inorgánica, Escuela de Química, Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, Vicuña Mackenna 4860, Macul, Santiago 7820436, Chile
1 shared publication - Iván Brito
Departamento de Química, Facultad de Ciencias Básicas, Universidad de Antofagasta, Av. Angamos 601, Antofagasta 1270300, Chile
1 shared publication - Mario Faúndez
Pharmacy Department, Faculty of Chemistry, Pontificia Universidad Católica de Chile, Vicuña Mackenna 4860, Santiago 7820436, Chile
1 shared publication - María Herrera-Maldonado
Departamento de Química, Facultad de Ciencias Naturales, Matemática y del Medio Ambiente, Universidad Tecnológica Metropolitana, Las Palmeras 3360, Ñuñoa, Santiago 7800003, Chile
1 shared publication - Michelle Palacios
Departamento de Química Inorgánica, Escuela de Química, Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, Vicuña Mackenna 4860, Macul, Santiago 7820436, Chile
1 shared publication
Latest Publications
- Open Access
- 19 May 2026
- Published by MDPI AG in Inorganics
- Vol. 14 (5) , 140
Toward Photoactivatable Copper(I) Anticancer Agents: Heteroleptic Cu(I) Complexes with Functionalized Dipyridylamine Ligands
In this study, we report the synthesis and characterization of three Cu(I) complexes bearing functionalized dipyridylamine ligands and DPEphos. Structural analysis confirms a distorted tetrahedral coordination environment around the metal center. Photophysical studies in DMSO show similar absorption profiles (λabs ≈ 341–343 nm) with ligand-centered and MLCT transitions, while emission spans the visible region (λemi = 410–483 nm) and is strongly influenced by ligand substitution, with the CF3 derivative displaying a marked red shift. Emission is insensitive to oxygen and exhibits short lifetimes (τ ≈ 14.9–15.3 ns), suggesting short-lived 1MLCT excited states. Biological evaluation in A375 melanoma cells reveals that all complexes exhibit low-micromolar cytotoxicity under dark conditions (IC50 = 3.33–4.92 μM). Notably, only the CF3-substituted complex shows a significant light-induced enhancement of activity upon irradiation at 390 nm (IC50 = 1.18 μM), indicating photoactivation.
- 19 May 2026
- Published by MDPI AG in Inorganics
- Vol. 14 (5) , 140
Open AccessToward Photoactivatable Copper(I) Anticancer Agents: Heteroleptic Cu(I) Complexes with Functionalized Dipyridylamine Ligands
In this study, we report the synthesis and characterization of three Cu(I) complexes bearing functionalized dipyridylamine ligands and DPEphos. Structural analysis confirms a distorted tetrahedral coordination environment around the metal center. Photophysical studies in DMSO show similar absorption profiles (λabs ≈ 341–343 nm) with ligand-centered and MLCT transitions, while emission spans the visible region (λemi = 410–483 nm) and is strongly influenced by ligand substitution, with the CF3 derivative displaying a marked red shift. Emission is insensitive to oxygen and exhibits short lifetimes (τ ≈ 14.9–15.3 ns), suggesting short-lived 1MLCT excited states. Biological evaluation in A375 melanoma cells reveals that all complexes exhibit low-micromolar cytotoxicity under dark conditions (IC50 = 3.33–4.92 μM). Notably, only the CF3-substituted complex shows a significant light-induced enhancement of activity upon irradiation at 390 nm (IC50 = 1.18 μM), indicating photoactivation.