Kaiqiao Yang
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Kaiqiao Yang has a total of 12 co-authors. Here are the top co-authors by number of shared publications:
Christian Lydersen
Research Department, Norwegian Polar Institute, Framsenteret
1 shared publication- Hideaki Mizobata
Department of Aquatic Bioscience, Graduate School of Agricultural and Life Sciences, The University of Tokyo
1 shared publication Jiancheng Liang
Department of Aquatic Bioscience, Graduate School of Agricultural and Life Sciences, The University of Tokyo
1 shared publicationKazutoshi Yoshitake
Department of Applied Biochemistry, School of Marine Science, Kitasato University
1 shared publicationKazuya Nishiwaki
Department of Aquatic Bioscience, Graduate School of Agricultural and Life Sciences, The University of Tokyo
1 shared publicationKit M. Kovacs
Research Department, Norwegian Polar Institute, Framsenteret
1 shared publication
Latest Publications
- Open Access
- 19 May 2026
- Published by National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 123 (21)
The Greenland shark genome: Insights into lifespan extremes and population dynamics
The Greenland shark ( Somniosus microcephalus ) is known for its slow metabolism and deep-sea habitat. It is thought to be the longest-lived vertebrate on Earth, with an estimated lifespan of 392 ± 120 y. Despite its remarkable longevity and unusual lifestyle, no genomic studies are yet available for this species. Here, we report a chromosome-level assembly of the Greenland shark genome, which is 5.9 Gb in size with an N50 length of 233 Mb and a completeness score of 96.7%. Our analyses of gene family expansion and positive selection revealed classical longevity-related mechanisms, including immune enhancement, cancer resistance, and DNA repair, as well as additional features potentially associated with extended lifespan limits. Unique amino acid substitutions in the globular domain of linker histone H1.0 are predicted to enhance chromatin stability, and the species’ distinctive gene repertoire provides a framework for generating hypotheses potentially linking ferroptosis to exceptional longevity. We also elucidate the dynamics of the effective population size ( N e ) of the Greenland shark and its close relative, the Pacific sleeper shark ( Somniosus pacificus ). These genomic analyses offer insights into the molecular basis of the exceptional longevity of the Greenland shark and highlight potential genetic mechanisms that could inform future research into longevity.
- 19 May 2026
- Published by National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 123 (21)
Open AccessThe Greenland shark genome: Insights into lifespan extremes and population dynamics
The Greenland shark ( Somniosus microcephalus ) is known for its slow metabolism and deep-sea habitat. It is thought to be the longest-lived vertebrate on Earth, with an estimated lifespan of 392 ± 120 y. Despite its remarkable longevity and unusual lifestyle, no genomic studies are yet available for this species. Here, we report a chromosome-level assembly of the Greenland shark genome, which is 5.9 Gb in size with an N50 length of 233 Mb and a completeness score of 96.7%. Our analyses of gene family expansion and positive selection revealed classical longevity-related mechanisms, including immune enhancement, cancer resistance, and DNA repair, as well as additional features potentially associated with extended lifespan limits. Unique amino acid substitutions in the globular domain of linker histone H1.0 are predicted to enhance chromatin stability, and the species’ distinctive gene repertoire provides a framework for generating hypotheses potentially linking ferroptosis to exceptional longevity. We also elucidate the dynamics of the effective population size ( N e ) of the Greenland shark and its close relative, the Pacific sleeper shark ( Somniosus pacificus ). These genomic analyses offer insights into the molecular basis of the exceptional longevity of the Greenland shark and highlight potential genetic mechanisms that could inform future research into longevity.