Xiangxiang Zhu
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Xiangxiang Zhu has a total of 7 co-authors. Here are the top co-authors by number of shared publications:
- Chenglin Wang
Faculty of Modern Agricultural Engineering, Kunming University of Science and Technology, Kunming 650504, China
1 shared publication - Dongbao Hu
Department of Chemistry and Environmental Engineering, Yuxi Normal University, Yuxi 653100, China
1 shared publication - Hui Yang
Faculty of Food Science and Engineering, Kunming University of Science and Technology, Kunming 650500, China
1 shared publication - Jiabao Cui
Faculty of Food Science and Engineering, Kunming University of Science and Technology, Kunming 650500, China
1 shared publication - Lingyi Liu
Food Science and Engineering Faculty, Kunming University of Science and Technology, Kunming 650500, China
1 shared publication - Shanshan Xiao
Faculty of Food Science and Engineering, Kunming University of Science and Technology, Kunming 650500, China
1 shared publication
Latest Publications
- Open Access
- 2 June 2026
- Published by MDPI AG in Pharmaceuticals
- Vol. 19 (6) , 886
Antibacterial, In Vitro Anti-Inflammatory and Anti-Acne Activities of Patchouli Essential Oil
Objectives: The study aimed to investigate the antibacterial, in vitro anti-inflammatory and anti-acne properties of Patchouli essential oil (PEO). Methods: PEO components were quantified by gas chromatography–mass spectrometry (GC-MS). The antibacterial activity of PEO against Cutibacterium acnes (C. acnes) and Staphylococcus epidermidis (S. epidermidis) was evaluated via MIC detection and growth curve analysis. Bacterial membrane integrity was assessed by detecting intracellular substance leakage. LPS-induced RAW264.7 cells inflammatory models and heat-inactivated C. acnes-stimulated human epidermal keratinocytes (HaCaT) cells acne models were constructed to explore the in vitro anti-inflammatory and anti-acne activities of PEO by measuring the secretion levels of pro-inflammatory cytokines. Results: PEO primarily contained α-guaiene, patchouli alcohol and α-bulnesene. It showed potent antibacterial activity with an MIC of 0.50 mg/mL, inhibiting bacterial growth and disrupting cell membrane integrity. PEO significantly alleviated cell damage and reduced the secretion of TNF-α, IL-1β and IL-6 in two inflammatory cell models, and suppressed excessive keratinocyte proliferation. Conclusions: PEO exerts anti-acne effects via dual antibacterial and anti-inflammatory pathways. This work provides valid experimental evidence for the application of PEO as a novel natural anti-acne agent.
- 2 June 2026
- Published by MDPI AG in Pharmaceuticals
- Vol. 19 (6) , 886
Open AccessAntibacterial, In Vitro Anti-Inflammatory and Anti-Acne Activities of Patchouli Essential Oil
Objectives: The study aimed to investigate the antibacterial, in vitro anti-inflammatory and anti-acne properties of Patchouli essential oil (PEO). Methods: PEO components were quantified by gas chromatography–mass spectrometry (GC-MS). The antibacterial activity of PEO against Cutibacterium acnes (C. acnes) and Staphylococcus epidermidis (S. epidermidis) was evaluated via MIC detection and growth curve analysis. Bacterial membrane integrity was assessed by detecting intracellular substance leakage. LPS-induced RAW264.7 cells inflammatory models and heat-inactivated C. acnes-stimulated human epidermal keratinocytes (HaCaT) cells acne models were constructed to explore the in vitro anti-inflammatory and anti-acne activities of PEO by measuring the secretion levels of pro-inflammatory cytokines. Results: PEO primarily contained α-guaiene, patchouli alcohol and α-bulnesene. It showed potent antibacterial activity with an MIC of 0.50 mg/mL, inhibiting bacterial growth and disrupting cell membrane integrity. PEO significantly alleviated cell damage and reduced the secretion of TNF-α, IL-1β and IL-6 in two inflammatory cell models, and suppressed excessive keratinocyte proliferation. Conclusions: PEO exerts anti-acne effects via dual antibacterial and anti-inflammatory pathways. This work provides valid experimental evidence for the application of PEO as a novel natural anti-acne agent.