JSJessica Denielle Matos dos Santos

Jessica Denielle Matos dos Santos

*This is an algorithmically generated author record based on publicly available information.

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Jessica Denielle Matos dos Santos has a total of 6 co-authors. Here are the top co-authors by number of shared publications:


Latest Publications

  • Open Access

    Resistance Training Attenuates Oxidative Stress and Muscle Damage and Improves the Quality of Induced Skin Lesions in Rats

    by José Uilien de Oliveira, Felipe J. Aidar, Jessica Denielle Matos dos Santos, Greice Itamaro Heiden, Ricardo Luiz Cavalcanti de Albuquerque-Júnior, Jymmys Lopes dos Santos, Pantelis T. Nikolaidis

    Resistance training (RT) can help with injury recovery and the healing process. Still, high-intensity exercise can cause ischemia and reperfusion, resulting in exacerbated production of reactive oxygen species and oxidative stress. This study aimed to evaluate the effects of RT with progressive loads on markers of tissue damage and oxidative stress in rats subjected to skin lesions. Forty male Wistar rats were used, divided into four groups (n = 10): Control (CG): no intervention; Sedentary Injury (SHAM): subjected to injury, no training; Training + Injury 1 (G1): injury after one week of training; Training + Injury 2 (G2): injury followed by training. The protocol consisted of climbing a vertical ladder three times a week, 48 h apart, using progressive loads (50%, 65%, and 80%). After euthanasia, markers of tissue damage (CK, LDH, ALT, AST), oxidative stress (MDA/TBARS, SH, uric acid), and histological analysis of collagen deposition in the injured tissue were assessed. Groups G1 and G2 showed a significant increase (p < 0.0001) in CK, LDH, ALT, and AST levels compared to GC and SHAM. Oxidative stress markers, such as MDA and SH, were also elevated in the G1 and G2 groups (p < 0.0001). Uric acid concentrations increased significantly in the exercised groups compared to the controls (p < 0.0001). Histology revealed an inflammatory infiltrate and disorganized collagen fibers in the SHAM group, while G1 and G2 showed tissue with greater cellular maturity and organization. Although RT induced muscle damage and an increase in pro-oxidant markers, it also favored cellular organization and scar tissue quality.