Franziska Grünfelder
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Franziska Grünfelder has a total of 6 co-authors. Here are the top co-authors by number of shared publications:
- Camillo T. Müller
Clinic for Plastic, Reconstructive & Aesthetic Surgery, Evangelical Clinics Essen-Mitte, 45136 Essen, Germany
1 shared publication - Ilker Uçkay
Infectiology, Unit for Clinical and Applied Research, Balgrist University Hospital, University of Zurich, 8008 Zurich, Switzerland
1 shared publication - Leila Harhaus
Plastic and Reconstructive Surgery, Burn Center, Department for Plastic Surgery, BG Klinik Trauma Center Ludwigshafen, University of Heidelberg, 67071 Ludwigshafen, Germany
1 shared publication - Martin Aman
BG Klinikum Unfallkrankenhaus Berlin, Department of Hand-, Replantation- and Microsurgery and Chair of Hand-, Replantation- and Microsurgery, Charité Universitätsmedizin Berlin, Berlin, Germany
1 shared publication - Ulrich Kneser
Department of Hand, Plastic and Reconstructive Surgery, Microsurgery, Burn Trauma Center, BG Trauma Center Ludwigshafen, University of Heidelberg, 67071 Ludwigshafen, Germany
1 shared publication - Valentin Haug
Berufsgenossenschaftliche Unfallklinik Ludwigshafen, Ludwigshafen am Rhein, Germany, Germany
1 shared publication
Latest Publications
- Open Access
- 16 June 2026
- Published by MDPI AG in Preprints.org
Predicting Amputation Among Six-Hundred Community-Acquired Hand Infections—A Surgical and Infectiology Cohort
Background/Objectives: Acute hand infections are common in emergency surgery. Amputation is the ultimate fate when antibiotics and the prior surgical repair fail. Unsurprisingly, clinician tend to exaggerate with the evidence-based indications of antibiotic treatment and flaps. Methods: We investigate 166 risk association of community-acquired (traumatic) hand infection with amputation, overall treatment failure and the necessity for a secondary flap, using a specifically-designed retrospective single-center cohort between March 2018 October 2020 in Germany. Results: Among 600 adult patients (362 males; 71 (11.8%) with diabetes mellitus), 58 (9.7%) required an amputation. Multivariate Cox regression analysis identified only inherent risks associated with "amputation": male sex (odds ratio [OR] 3.12, 95% confidence interval [CI] 1.28-7.69), advanced age (OR 1.03, 95% CI 1.01-1.04), diabetes (OR 2.40, 95% CI 1.15-5.01, whereas all interventional variables such as early flapping or antibiotic-related parameters (early empiric antibiotic use, total duration of antibiotics and of tits parenteral part, choice of agents,) could not alter outcomes. Conclusions: In severe (traumatic) hand infections among adult German patients, the outcomes are determined by the extent of trauma and underlying co-morbidities. The outcomes do not seem to be effectively reduced by exaggerations of the indication of surgical or antibiotic interventions.
- 16 June 2026
- Published by MDPI AG in Preprints.org
Open AccessPredicting Amputation Among Six-Hundred Community-Acquired Hand Infections—A Surgical and Infectiology Cohort
Background/Objectives: Acute hand infections are common in emergency surgery. Amputation is the ultimate fate when antibiotics and the prior surgical repair fail. Unsurprisingly, clinician tend to exaggerate with the evidence-based indications of antibiotic treatment and flaps. Methods: We investigate 166 risk association of community-acquired (traumatic) hand infection with amputation, overall treatment failure and the necessity for a secondary flap, using a specifically-designed retrospective single-center cohort between March 2018 October 2020 in Germany. Results: Among 600 adult patients (362 males; 71 (11.8%) with diabetes mellitus), 58 (9.7%) required an amputation. Multivariate Cox regression analysis identified only inherent risks associated with "amputation": male sex (odds ratio [OR] 3.12, 95% confidence interval [CI] 1.28-7.69), advanced age (OR 1.03, 95% CI 1.01-1.04), diabetes (OR 2.40, 95% CI 1.15-5.01, whereas all interventional variables such as early flapping or antibiotic-related parameters (early empiric antibiotic use, total duration of antibiotics and of tits parenteral part, choice of agents,) could not alter outcomes. Conclusions: In severe (traumatic) hand infections among adult German patients, the outcomes are determined by the extent of trauma and underlying co-morbidities. The outcomes do not seem to be effectively reduced by exaggerations of the indication of surgical or antibiotic interventions.