Yiheng Wang
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Yiheng Wang has a total of 6 co-authors. Here are the top co-authors by number of shared publications:
- Hanyu Li
Hunan Key Laboratory of Vascular Biology and Translational Medicine, Medical School, Hunan University of Chinese Medicine, Changsha 410208, China
1 shared publication - Mei Yang
Hunan Key Laboratory of Vascular Biology and Translational Medicine, Medical School, Hunan University of Chinese Medicine, Changsha 410208, China
1 shared publication - Wei Hu
Department of Integrated Traditional Chinese and Western Medicine, Xiangya Boai Rehabilitation Hospital, Changsha 410151, China
1 shared publication - Xiaoxu Yang
Hunan Key Laboratory of Vascular Biology and Translational Medicine, Medical School, Hunan University of Chinese Medicine, Changsha 410208, China
1 shared publication - Xihua Cheng
Hunan Key Laboratory of Vascular Biology and Translational Medicine, Medical School, Hunan University of Chinese Medicine, Changsha 410208, China
1 shared publication - Yancheng Zhong
Hunan Key Laboratory of Vascular Biology and Translational Medicine, Medical School, Hunan University of Chinese Medicine, Changsha 410208, China
1 shared publication
Latest Publications
- Open Access
The Interaction Between Insulin Resistance and Neuroinflammation in the Brain and Its Impact on Diabetic Encephalopathy
Diabetic encephalopathy (DE) is a severe complication of diabetes mellitus affecting the central nervous system (CNS), characterized by cognitive dysfunction. This review systematically explores how the interplay between brain insulin resistance (BIR) and neuroinflammation contributes to the pathogenesis of DE. BIR refers to the diminished responsiveness of the CNS to insulin signaling, resulting in the suppression of the PI3K/Akt and MAPK pathways, impaired glucose metabolism, and dysfunction across multiple neural cell types—including neurons, astrocytes, microglia, brain endothelial cells, and oligodendrocytes. These disturbances manifest as impaired energy metabolism, compromised synaptic plasticity, disruption of the blood–brain barrier, and reduced myelination. Importantly, BIR and neuroinflammation form a vicious cycle within these cells, mutually exacerbating each other and jointly driving the pathological progression of DE. Finally, we have compiled a list of currently available drugs that can improve BIR and suppress neuroinflammation, along with the latest progress in clinical trials, to provide new insights for the future of precision treatment for DE.
Open AccessThe Interaction Between Insulin Resistance and Neuroinflammation in the Brain and Its Impact on Diabetic Encephalopathy
Diabetic encephalopathy (DE) is a severe complication of diabetes mellitus affecting the central nervous system (CNS), characterized by cognitive dysfunction. This review systematically explores how the interplay between brain insulin resistance (BIR) and neuroinflammation contributes to the pathogenesis of DE. BIR refers to the diminished responsiveness of the CNS to insulin signaling, resulting in the suppression of the PI3K/Akt and MAPK pathways, impaired glucose metabolism, and dysfunction across multiple neural cell types—including neurons, astrocytes, microglia, brain endothelial cells, and oligodendrocytes. These disturbances manifest as impaired energy metabolism, compromised synaptic plasticity, disruption of the blood–brain barrier, and reduced myelination. Importantly, BIR and neuroinflammation form a vicious cycle within these cells, mutually exacerbating each other and jointly driving the pathological progression of DE. Finally, we have compiled a list of currently available drugs that can improve BIR and suppress neuroinflammation, along with the latest progress in clinical trials, to provide new insights for the future of precision treatment for DE.