Adriana María Loor Vélez

Tissue bioengineering and regenerative aesthetic medicine have emerged as rapidly evolving interdisciplinary fields that integrate plastic surgery, regenerative medicine, endocrinology, molecular biology, biomaterials science, and biomedical engineering to promote tissue restoration and functional recovery. The objective of this review was to analyze current advances in regenerative technologies and their applications in aesthetic and reconstructive medicine. A comprehensive review of scientific literature indexed in major biomedical databases was conducted, focusing on stem cell therapies, platelet-rich plasma, extracellular vesicles, bioactive scaffolds, biomaterials, and three-dimensional bioprinting. The analyzed evidence demonstrated that adipose-derived stem cells and platelet-rich plasma remain the most established regenerative interventions due to their favorable safety profiles, accessibility, and demonstrated effectiveness in tissue repair and rejuvenation. Emerging technologies such as exosome-based therapies and advanced tissue-engineering platforms exhibited significant innovation potential and may contribute to future therapeutic developments. Angiogenesis, extracellular matrix remodeling, cellular signaling, and endocrine regulation were identified as essential mechanisms underlying successful regenerative outcomes. Furthermore, the findings highlighted the increasing importance of personalized regenerative approaches that incorporate metabolic and hormonal optimization. Despite substantial progress, challenges related to protocol standardization, long-term clinical validation, regulatory frameworks, and accessibility remain significant barriers to widespread implementation. Overall, tissue bioengineering and regenerative aesthetic medicine represent promising strategies capable of transforming contemporary healthcare by promoting biological restoration, improving aesthetic outcomes, and advancing personalized therapeutic interventions.

Advanced reconstruction has become an essential component of modern oncologic care, particularly for patients undergoing mastectomy for breast cancer and those requiring reconstruction following skin cancer excision. The objective of this review was to analyze contemporary evidence regarding reconstructive strategies, clinical outcomes, patient-centered benefits, and emerging innovations in reconstructive oncology. A narrative and integrative literature review was conducted using scientific publications retrieved from major biomedical databases, including PubMed, Scopus, ScienceDirect, Web of Science, and Google Scholar. The reviewed evidence demonstrated that implant-based reconstruction, autologous tissue reconstruction, microsurgical procedures, local flaps, skin grafting techniques, and acellular dermal matrix-assisted approaches constitute the principal reconstructive modalities currently employed in oncologic practice. Implant-based reconstruction remains the most widely utilized option, whereas autologous and microsurgical techniques frequently provide superior long-term aesthetic and functional outcomes. In dermatologic oncology, local flap reconstruction continues to represent a highly effective solution for restoring complex anatomical regions while preserving function and cosmetic appearance. Patient-centered outcomes, including quality of life, body image, emotional well-being, social reintegration, and long-term satisfaction, were consistently identified as important indicators of reconstructive success. The findings also highlight the growing importance of multidisciplinary collaboration and individualized treatment planning in optimizing outcomes. Emerging technologies such as regenerative medicine, tissue engineering, bioengineered scaffolds, three-dimensional surgical planning, and artificial intelligence-assisted decision-making may further enhance reconstructive precision and patient care in the future. Overall, advanced reconstruction plays a critical role in improving functional recovery, aesthetic restoration, psychosocial adaptation, and survivorship among patients affected by breast cancer and cutaneous malignancies.

Hepatobiliary surgery remains one of the most technically demanding areas of modern surgical practice due to the complexity of hepatic and biliary anatomy, the need for precise lesion localization, and the risk of major intraoperative complications. In recent years, advances in artificial intelligence (AI), intraoperative imaging, and radiological navigation technologies have introduced new opportunities to improve surgical planning, procedural accuracy, and patient safety. This review analyzes the current evidence regarding the integration of AI-assisted technologies and intraoperative radiological navigation in hepatobiliary surgery. A narrative literature review was conducted using scientific publications retrieved from major international databases, including PubMed/MEDLINE, Scopus, Web of Science, ScienceDirect, SpringerLink, Wiley Online Library, and Google Scholar. The reviewed literature demonstrated a substantial increase in research activity during the last decade, particularly in areas involving machine learning, deep learning, computer vision, three-dimensional reconstruction, fluorescence-guided imaging, augmented reality, robotic-assisted surgery, and intelligent navigation systems. The findings indicate that these technologies contribute to improved preoperative planning, enhanced anatomical visualization, greater intraoperative precision, and more effective decision-making. Furthermore, increasing integration among artificial intelligence platforms, advanced imaging modalities, and robotic technologies suggests the emergence of comprehensive digital surgical ecosystems designed to support precision surgery. Although challenges related to implementation costs, technological accessibility, infrastructure, and clinical validation remain, current evidence supports the growing incorporation of these innovations into hepatobiliary surgical practice. Continued research and international collaboration will be essential for optimizing their clinical application and expanding access to advanced surgical technologies worldwide.