Chloe Zhao
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Chloe Zhao has a total of 8 co-authors. Here are the top co-authors by number of shared publications:
- Catie Kaneshiro
Molecular Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD
1 shared publication - Dana Bakalar
Molecular Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD
1 shared publication - Elizabeth Purdom
UC Berkeley
1 shared publication - John Ngai
National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, USA
1 shared publication - Kelly Street
Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California
1 shared publication - Sandrine Dudoit
University of California, Berkeley
1 shared publication
Latest Publications
- Open Access
Evolving stem cell fate capacities and transcriptional priming in the developing olfactory epithelium
The olfactory epithelium of adult mammals contains two populations of stem cells that support its remarkable ability to regenerate neuronal and non-neuronal cell types throughout life. How olfactory epithelial cell types are established during development, however, is not well understood. Here, we use genetic lineage tracing and single-cell RNA sequencing of the perinatal mouse olfactory epithelium to construct a developmental trajectory consisting of multiple lineages. We identify transitional states and lineage relationships between individual cells and establish Ascl1 + cells as the primary multipotent progenitors in the perinatal olfactory epithelium. Further, Ascl1 + cells become progressively restricted in their cell fate capacity over developmental time and appear to be transcriptionally primed toward specific lineages. We also predict signaling pathways that may contribute to lineage plasticity and niche permissiveness. Together, these results contribute to our understanding of how cell-intrinsic and -extrinsic signals contribute to the establishment of a stem cell niche.
Open AccessEvolving stem cell fate capacities and transcriptional priming in the developing olfactory epithelium
The olfactory epithelium of adult mammals contains two populations of stem cells that support its remarkable ability to regenerate neuronal and non-neuronal cell types throughout life. How olfactory epithelial cell types are established during development, however, is not well understood. Here, we use genetic lineage tracing and single-cell RNA sequencing of the perinatal mouse olfactory epithelium to construct a developmental trajectory consisting of multiple lineages. We identify transitional states and lineage relationships between individual cells and establish Ascl1 + cells as the primary multipotent progenitors in the perinatal olfactory epithelium. Further, Ascl1 + cells become progressively restricted in their cell fate capacity over developmental time and appear to be transcriptionally primed toward specific lineages. We also predict signaling pathways that may contribute to lineage plasticity and niche permissiveness. Together, these results contribute to our understanding of how cell-intrinsic and -extrinsic signals contribute to the establishment of a stem cell niche.