Chenyu Song
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Chenyu Song has a total of 11 co-authors. Here are the top co-authors by number of shared publications:
- Bo Wen
College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang 453000, China
1 shared publication - Bo Yang
Shanxi Key Laboratory of Animal Disease Research, Prevention and Control, College of Veterinary Medicine, Shanxi Agricultural University, Taigu 030801, China
1 shared publication - Ding Zhang
College of Veterinary Medicine, Shanxi Agricultural University, Taigu, Jinzhong 030801, China
1 shared publication - Hanwei Yin
Shanxi Key Laboratory of Animal Disease Research, Prevention and Control, College of Veterinary Medicine, Shanxi Agricultural University, Taigu, Jinzhong 030801, China
1 shared publication - Hongnuan Wang
Shanxi Key Laboratory of Animal Disease Research, Prevention and Control, College of Veterinary Medicine, Shanxi Agricultural University, Taigu, Jinzhong 030801, China
1 shared publication - Jingyu Wang
College of Veterinary Medicine, Northwest A&F University, Yangling 712100, China
1 shared publication
Latest Publications
- Open Access
Peste Des Petits Ruminants Virus Infection Induces Syncytium Formation via RhoA-Rock1 Signaling Pathway to Promote Viral Replication
Peste des petits ruminants (PPR) is an acute, severe, and highly contagious disease caused by peste des petits ruminants virus (PPRV), which primarily induces tissue damage through the formation of syncytia. Therefore, elucidating the molecular mechanism underlying PPRV-induced syncytium formation is of critical importance. In this study, we generated Vero CCL-81 cell lines stably expressing the PPRV receptors SLAM (lymphocytic) or Nectin-4 (epithelial) and further found that PPRV infection significantly induced syncytium formation in these cell lines as well as in goat mammary epithelial cells (GMECs) and ovine rumen epithelial cells (ORECs). Furthermore, the viral H and F proteins served as the pivotal determinants of syncytium formation. More importantly, we discovered that PPRV-induced syncytium formation is dependent on the RhoA-Rock1 signaling pathway and that inhibition of syncytium formation markedly suppressed PPRV replication. Collectively, our findings provide novel insights into the molecular mechanism of PPRV-induced syncytium formation, offer theoretical references for the development of new antiviral strategies, and advance the scientific eradication of PPR.
Open AccessPeste Des Petits Ruminants Virus Infection Induces Syncytium Formation via RhoA-Rock1 Signaling Pathway to Promote Viral Replication
Peste des petits ruminants (PPR) is an acute, severe, and highly contagious disease caused by peste des petits ruminants virus (PPRV), which primarily induces tissue damage through the formation of syncytia. Therefore, elucidating the molecular mechanism underlying PPRV-induced syncytium formation is of critical importance. In this study, we generated Vero CCL-81 cell lines stably expressing the PPRV receptors SLAM (lymphocytic) or Nectin-4 (epithelial) and further found that PPRV infection significantly induced syncytium formation in these cell lines as well as in goat mammary epithelial cells (GMECs) and ovine rumen epithelial cells (ORECs). Furthermore, the viral H and F proteins served as the pivotal determinants of syncytium formation. More importantly, we discovered that PPRV-induced syncytium formation is dependent on the RhoA-Rock1 signaling pathway and that inhibition of syncytium formation markedly suppressed PPRV replication. Collectively, our findings provide novel insights into the molecular mechanism of PPRV-induced syncytium formation, offer theoretical references for the development of new antiviral strategies, and advance the scientific eradication of PPR.