Caner Simsir
Research Subjects
Caner Simsir has a total of 4 co-authors. Here are the top co-authors by number of shared publications:
Kerem Yılmaz
Department ofPathology, Hacettepe University Faculty of Medicine
1 shared publication- Mehmet Ruhi Onur
Department of Radiology, Hacettepe University Faculty of Medicine, Ankara, Turkey
1 shared publication - Murat Tuncel
Department of Nuclear Medicine, Hacettepe University, 06230 Ankara, Turkey
1 shared publication - Saadettin Kilickap
Department of Medical Oncology, Faculty of Medicine, İstinye University, İstanbul 34010, Turkey
1 shared publication
Latest Publications
- 10 July 2026
- Published by Wolters Kluwer Health in Clinical Nuclear Medicine
Intracholecystic Papillary Neoplasm Mimicking High-Grade Dedifferentiation in a Patient With Neuroendocrine Tumor: The Value of Dual-Tracer PET/CT
A 50-year-old man with weight loss and fatigue was diagnosed with a grade 2 liver-metastatic neuroendocrine tumor (NET). Dual-tracer molecular imaging was performed for staging and characterization. While 18 F-FDG PET/CT showed focal high uptake in a gallbladder lesion (SUVmax: 10) and non-FDG-avid liver metastases, 68 Ga-DOTATATE PET/CT revealed intense somatostatin receptor expression in the primary pancreatic lesion and liver metastases, but no uptake in the gallbladder. This discordant “flip-flop” pattern typically suggests high-grade dedifferentiation. However, histopathology following cholecystectomy revealed a low-grade intracholecystic papillary neoplasm (ICPN). This case highlights that discordant FDG-positive/SSTR-negative foci in NET patients can represent rare premalignant mimics rather than aggressive tumor biology.
- 10 July 2026
- Published by Wolters Kluwer Health in Clinical Nuclear Medicine
Intracholecystic Papillary Neoplasm Mimicking High-Grade Dedifferentiation in a Patient With Neuroendocrine Tumor: The Value of Dual-Tracer PET/CT
A 50-year-old man with weight loss and fatigue was diagnosed with a grade 2 liver-metastatic neuroendocrine tumor (NET). Dual-tracer molecular imaging was performed for staging and characterization. While 18 F-FDG PET/CT showed focal high uptake in a gallbladder lesion (SUVmax: 10) and non-FDG-avid liver metastases, 68 Ga-DOTATATE PET/CT revealed intense somatostatin receptor expression in the primary pancreatic lesion and liver metastases, but no uptake in the gallbladder. This discordant “flip-flop” pattern typically suggests high-grade dedifferentiation. However, histopathology following cholecystectomy revealed a low-grade intracholecystic papillary neoplasm (ICPN). This case highlights that discordant FDG-positive/SSTR-negative foci in NET patients can represent rare premalignant mimics rather than aggressive tumor biology.