Natalia Santa Cruz
Research Subjects
Natalia Santa Cruz has a total of 7 co-authors. Here are the top co-authors by number of shared publications:
- Alejandro Berra
Centro de Medicina Traslacional Hospital El Cruce (CEMET-HEC), Argentina
1 shared publication - Ana Vanesa Torbidoni
Hematology-Oncology Service, Pediatric Hospital S.A.M.I.C. Prof. Dr. Juan P. Garrahan, Buenos Aires, Argentina
1 shared publication - Flavia Mariana Michelini
Centro de Medicina Traslacional, Hospital El Cruce (CEMET-HEC), Florencio Varela, Argentina., Argentina
1 shared publication - Griselda Noemí Moreno
Instituto de Ciencias de la Salud, Universidad Nacional Arturo Jauretche, Florencio Varela, Argentina, Argentina
1 shared publication - María Ximena Guerbi
Centro de Medicina Traslacional Hospital El Cruce (CEMET-HEC), Argentina
1 shared publication - Matías Fabián Rotela
Centro de Medicina Traslacional Hospital El Cruce (CEMET-HEC), Argentina
1 shared publication
Latest Publications
- Open Access
- 11 August 2026
- Published by MDPI AG in Preprints.org
Industrial Particulate Matter and Hyperosmolar Stress Induce Oxidative Damage in Ocular Surface and Immune Cells: Protective Effects of Human Amniotic Membrane Extract
Airborne particulate matter (PM₂.₅) contributes to oxidative damage of the ocular surface, particularly under dry eye-related hyperosmolar conditions. We evaluated the protective effects of a soluble extract derived from lyophilized human amniotic membrane patches (hAM-Te) in human corneal and conjunctival epithelial cells and THP-1 macrophages exposed to hyperosmolarity, industrial PM₂.₅, or both. Cell viability, migration, reactive oxygen species, nitrite production, total antioxidant capacity, and antioxidant enzyme activities were assessed. Combined hyperosmolarity and PM₂.₅ markedly impaired cell viability and migration while increasing oxidative and nitrosative stress. hAM-Te significantly improved cell viability and wound closure, reduced reactive oxygen species and nitrite levels, restored antioxidant capacity, and modulated endogenous antioxidant defenses. These findings demonstrate that hAM-Te attenuates redox imbalance and cellular injury induced by combined environmental and hyperosmolar stress, supporting its potential as a protective strategy against pollution-associated ocular surface damage.
- 11 August 2026
- Published by MDPI AG in Preprints.org
Open AccessIndustrial Particulate Matter and Hyperosmolar Stress Induce Oxidative Damage in Ocular Surface and Immune Cells: Protective Effects of Human Amniotic Membrane Extract
Airborne particulate matter (PM₂.₅) contributes to oxidative damage of the ocular surface, particularly under dry eye-related hyperosmolar conditions. We evaluated the protective effects of a soluble extract derived from lyophilized human amniotic membrane patches (hAM-Te) in human corneal and conjunctival epithelial cells and THP-1 macrophages exposed to hyperosmolarity, industrial PM₂.₅, or both. Cell viability, migration, reactive oxygen species, nitrite production, total antioxidant capacity, and antioxidant enzyme activities were assessed. Combined hyperosmolarity and PM₂.₅ markedly impaired cell viability and migration while increasing oxidative and nitrosative stress. hAM-Te significantly improved cell viability and wound closure, reduced reactive oxygen species and nitrite levels, restored antioxidant capacity, and modulated endogenous antioxidant defenses. These findings demonstrate that hAM-Te attenuates redox imbalance and cellular injury induced by combined environmental and hyperosmolar stress, supporting its potential as a protective strategy against pollution-associated ocular surface damage.