Marine Clavaud
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Marine Clavaud has a total of 12 co-authors. Here are the top co-authors by number of shared publications:
- Agnès Church
Université de Paris Cité, Paris, France; Department of Pediatric Anesthesia and Intensive Care, Necker-Enfants–Malades University Hospital, Assistance Publique–Hôpitaux de Paris, Paris, France; UMR 1343, Pharmacologie et Évaluation des Thérapeutiques Chez l’Enfant et la Femme Enceinte, INSERM, Université Paris Cité, Paris, France
1 shared publication - Amélie Jurine
Department of Pediatric Anesthesia and Intensive Care, Jean Minjoz University Hospital, Besancon, France
1 shared publication - Clémentine Cholet
Department of Anesthesia and Intensive Care, Robert Debré University Hospital, Paris, France; Université de Paris Cité, Paris, France; University Hospital Department PROTECT INSERM U 1141, Robert Debré University Hospital, Paris, France
1 shared publication - Florence Julien-Marsollier
Service d'anesthésie-réanimation, Hôpital Robert-Debré, 48 boulevard Sérurier, 75019 Paris, France
1 shared publication - Gilles Orliaguet
Université de Paris Cité, Paris, France; Department of Pediatric Anesthesia and Intensive Care, Necker-Enfants–Malades University Hospital, Assistance Publique–Hôpitaux de Paris; UMR 1343, Pharmacologie et Évaluation des Thérapeutiques Chez l’Enfant et la Femme Enceinte, INSERM, Université Paris Cité, Paris, France
1 shared publication - Isabelle Constant
Département d’Anesthésie, Hôpital Armand Trousseau, Assistance Publique - Hôpitaux de Paris
1 shared publication
Latest Publications
- 3 August 2026
- Published by Wolters Kluwer Health in Anesthesiology
- Vol. 145 (6) , 1423-1432
Effects of Intraoperative Nociception Monitoring during Adolescent Idiopathic Scoliosis Correction
Background: Reducing postoperative opioid consumption has become a significant challenge in perioperative pain management, particularly within the framework of Enhanced Recovery After Surgery protocols and the associated risk of prolonged opioid dependence. The primary objective of this study was to evaluate whether remifentanil administration guided by intraoperative nociception monitoring with the Analgesia Nociception Index (ANI) during surgery for adolescent idiopathic scoliosis reduces postoperative morphine consumption at day 1. The secondary objective was the incidence of persistent postoperative pain 6 months after surgery. Methods: The current study, a multicenter randomized controlled trial, was conducted between October 2020 and June 2023. Eligible children were randomly assigned to receive intraoperative remifentanil administration guided either by hemodynamic parameters (control group) or by the Analgesia Nociception Index (intervention group). Comparison of postoperative morphine use was adjusted to the use of nonopioid analgesics. Results: Overall, 247 patients were included, and 244 were randomized (120 in the ANI group and 123 in the control group). Postoperative morphine consumption at day 1 was similar in both groups (median [25%; 75% interquartile range], 0.4 [0.3; 0.8] vs . 0.4 [0.3; 0.5] in the ANI and control groups, respectively; median difference [95% CI] = −0.005[−0.10 to 0.09] mg · kg −1 ; P = 0.93). Intraoperative remifentanil administration decreased in the ANI group (mean difference [95% CI], 9.5 [4 to 15] μg ·kg −1 , P < 0.001). ANI-guided intraoperative remifentanil administration did not result in differences in secondary outcomes. Conclusions: The administration of remifentanil guided by intraoperative nociception monitoring during adolescent idiopathic scoliosis did not result in a reduction of postoperative opioid consumption.
- 3 August 2026
- Published by Wolters Kluwer Health in Anesthesiology
- Vol. 145 (6) , 1423-1432
Effects of Intraoperative Nociception Monitoring during Adolescent Idiopathic Scoliosis Correction
Background: Reducing postoperative opioid consumption has become a significant challenge in perioperative pain management, particularly within the framework of Enhanced Recovery After Surgery protocols and the associated risk of prolonged opioid dependence. The primary objective of this study was to evaluate whether remifentanil administration guided by intraoperative nociception monitoring with the Analgesia Nociception Index (ANI) during surgery for adolescent idiopathic scoliosis reduces postoperative morphine consumption at day 1. The secondary objective was the incidence of persistent postoperative pain 6 months after surgery. Methods: The current study, a multicenter randomized controlled trial, was conducted between October 2020 and June 2023. Eligible children were randomly assigned to receive intraoperative remifentanil administration guided either by hemodynamic parameters (control group) or by the Analgesia Nociception Index (intervention group). Comparison of postoperative morphine use was adjusted to the use of nonopioid analgesics. Results: Overall, 247 patients were included, and 244 were randomized (120 in the ANI group and 123 in the control group). Postoperative morphine consumption at day 1 was similar in both groups (median [25%; 75% interquartile range], 0.4 [0.3; 0.8] vs . 0.4 [0.3; 0.5] in the ANI and control groups, respectively; median difference [95% CI] = −0.005[−0.10 to 0.09] mg · kg −1 ; P = 0.93). Intraoperative remifentanil administration decreased in the ANI group (mean difference [95% CI], 9.5 [4 to 15] μg ·kg −1 , P < 0.001). ANI-guided intraoperative remifentanil administration did not result in differences in secondary outcomes. Conclusions: The administration of remifentanil guided by intraoperative nociception monitoring during adolescent idiopathic scoliosis did not result in a reduction of postoperative opioid consumption.