Hong Ming Glendon Ong
Research Subjects
Hong Ming Glendon Ong has a total of 9 co-authors. Here are the top co-authors by number of shared publications:
- Joanna Khoo
National Centre for Food Science, Singapore Food Agency, 7 International Business Park, Singapore 609919, Singapore
1 shared publication - Joanne Sheot Harn Chan
National Centre for Food Science, Singapore Food Agency, 7 International Business Park, Singapore 609919, Singapore
1 shared publication - Kyaw Thu Aung
National Centre for Food Science, Singapore Food Agency, 7 International Business Park, Singapore 609919 Singapore; School of Biological Sciences, Nanyang Technological University, 60 Nanyang Dr, Singapore 637551 Singapore
1 shared publication - Matthias Maiwald
Department of Pathology and Laboratory Medicine, KK Women’s and Children’s Hospital, Singapore 229899, Singapore
1 shared publication - Pandora Han
National Centre for Food Science, Singapore Food Agency, Singapore 609919, Singapore
1 shared publication - Timothy Barkham
Tan Tock Seng Hospital
1 shared publication
Latest Publications
- Open Access
- 8 September 2026
- Published by MDPI AG in Microorganisms
- Vol. 14 (9) , 1990
Whole-Genome Sequencing-Based Characterisation of Salmonella Saintpaul Isolates from Human and Food Sources in Singapore: Sequence Types, Antimicrobial Resistance and Plasmid Profiles
Salmonella Saintpaul is a foodborne pathogen of public health relevance. This study characterised 79 S. Saintpaul isolates from human clinical and food sources collected in Singapore from 2015 to 2017. Isolates belonged to ST3602 (91.1%, n = 72), ST27 (6.33%, n = 5), ST49 (1.27%, n = 1) or ST50 (1.27%, n = 1). ST3602 predominated in both human (92.5%) and food (89.7%) isolates. Human and food isolates showed the highest resistance to penicillins and beta-lactam/beta-lactamase inhibitor combinations. The analysis identified beta-lactam resistance genes (blaCTX-M-1, blaTEM-1D), aminoglycoside resistance genes (aph(4)-Ia, aac(3)-IVa, aadA), and fluoroquinolone resistance genes (qnrS) as the most prevalent. Notably, 31.6% of isolates identified as extended-spectrum beta-lactamase (ESBL)-producing and all ESBL-positive isolates exhibited multidrug resistance. Plasmids were predicted in 75.9% (n = 60) of the isolates, with IncI1-I(Alpha) being the most common incompatibility group and showing a strong association with blaCTX-M-1 (Fisher’s exact test, p < 0.001; Φ = 0.913). Single-nucleotide polymorphism (SNP) analysis revealed close genetic relatedness between chicken and human isolates at relatively low SNP distances (0–16 SNPs), suggesting potential shared transmission pathways. This study provides epidemiological insights and antimicrobial resistance landscape of S. Saintpaul in Singapore, informing strategies for food safety and public health surveillance.
- 8 September 2026
- Published by MDPI AG in Microorganisms
- Vol. 14 (9) , 1990
Open AccessWhole-Genome Sequencing-Based Characterisation of Salmonella Saintpaul Isolates from Human and Food Sources in Singapore: Sequence Types, Antimicrobial Resistance and Plasmid Profiles
Salmonella Saintpaul is a foodborne pathogen of public health relevance. This study characterised 79 S. Saintpaul isolates from human clinical and food sources collected in Singapore from 2015 to 2017. Isolates belonged to ST3602 (91.1%, n = 72), ST27 (6.33%, n = 5), ST49 (1.27%, n = 1) or ST50 (1.27%, n = 1). ST3602 predominated in both human (92.5%) and food (89.7%) isolates. Human and food isolates showed the highest resistance to penicillins and beta-lactam/beta-lactamase inhibitor combinations. The analysis identified beta-lactam resistance genes (blaCTX-M-1, blaTEM-1D), aminoglycoside resistance genes (aph(4)-Ia, aac(3)-IVa, aadA), and fluoroquinolone resistance genes (qnrS) as the most prevalent. Notably, 31.6% of isolates identified as extended-spectrum beta-lactamase (ESBL)-producing and all ESBL-positive isolates exhibited multidrug resistance. Plasmids were predicted in 75.9% (n = 60) of the isolates, with IncI1-I(Alpha) being the most common incompatibility group and showing a strong association with blaCTX-M-1 (Fisher’s exact test, p < 0.001; Φ = 0.913). Single-nucleotide polymorphism (SNP) analysis revealed close genetic relatedness between chicken and human isolates at relatively low SNP distances (0–16 SNPs), suggesting potential shared transmission pathways. This study provides epidemiological insights and antimicrobial resistance landscape of S. Saintpaul in Singapore, informing strategies for food safety and public health surveillance.