Di Han
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Di Han has a total of 10 co-authors. Here are the top co-authors by number of shared publications:
- Chang Liu
State key laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine, National Chinmedomics Research Center, Metabolomics Laboratory, Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Heping Road 24, Harbin 150040, China
1 shared publication - Hui Sun
State Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine, National Chinmedomics Research Center, National TCM Key Laboratory of Serum Pharmacochemistry, Metabolomics Laboratory, Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, China
1 shared publication - Ling Kong
State key laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine, National Chinmedomics Research Center, Metabolomics Laboratory, Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Heping Road 24, Harbin 150040, China
1 shared publication - Qichao Liang
State key laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine, National Chinmedomics Research Center, Metabolomics Laboratory, Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Heping Road 24, Harbin 150040, China
1 shared publication - Xijun Wang
State Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine, National Chinmedomics Research Center, National TCM Key Laboratory of Serum Pharmacochemistry, Metabolomics Laboratory, Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, China
1 shared publication - Xiwu Zhang
State key laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine, National Chinmedomics Research Center, Metabolomics Laboratory, Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Heping Road 24, Harbin 150040, China
1 shared publication
Latest Publications
- Open Access
- 3 October 2026
- Published by MDPI AG in International Journal of Molecular Sciences
- Vol. 27 (19) , 8850
Extraction, Structure–Activity Relationships, and Modification of Plant-Derived Polysaccharides: An Integrated Framework for Evidence-Based Method Selection and Bioactivity Optimization—A Review
Extensive research has been conducted on plant-derived polysaccharides, yet three interrelated challenges remain insufficiently explored: extraction methods are often selected without systematic validation; the structure–activity relationship (SAR) remains fragmented; and modification strategies are rarely designed on the basis of SAR knowledge. This article systematically summarizes three key aspects: extraction, SAR, and structural modification. We critically compare various extraction techniques and clarify that method selection requires consideration of source characteristics and application orientation. We also demonstrate that extraction conditions may affect structural integrity and, consequently, influence biological activity. Subsequently, we analyze SAR by examining molecular weight, monosaccharide composition, glycosidic linkages, uronic acid content, and chain conformation to identify structural determinants of biological functions. Finally, we review chemical modification strategies and illustrate how their efficacy depends on structural features initially determined by extraction. By integrating evidence from these three stages, this review offers a practical framework to support rational, evidence-based development of plant-derived polysaccharides for applications in medicine, food, and biomaterials.
- 3 October 2026
- Published by MDPI AG in International Journal of Molecular Sciences
- Vol. 27 (19) , 8850
Open AccessExtraction, Structure–Activity Relationships, and Modification of Plant-Derived Polysaccharides: An Integrated Framework for Evidence-Based Method Selection and Bioactivity Optimization—A Review
Extensive research has been conducted on plant-derived polysaccharides, yet three interrelated challenges remain insufficiently explored: extraction methods are often selected without systematic validation; the structure–activity relationship (SAR) remains fragmented; and modification strategies are rarely designed on the basis of SAR knowledge. This article systematically summarizes three key aspects: extraction, SAR, and structural modification. We critically compare various extraction techniques and clarify that method selection requires consideration of source characteristics and application orientation. We also demonstrate that extraction conditions may affect structural integrity and, consequently, influence biological activity. Subsequently, we analyze SAR by examining molecular weight, monosaccharide composition, glycosidic linkages, uronic acid content, and chain conformation to identify structural determinants of biological functions. Finally, we review chemical modification strategies and illustrate how their efficacy depends on structural features initially determined by extraction. By integrating evidence from these three stages, this review offers a practical framework to support rational, evidence-based development of plant-derived polysaccharides for applications in medicine, food, and biomaterials.