Supplemental Figure 7 from Defective DNA Damage Response Is a Targetable Therapeutic Vulnerability in ESR1-Mutant Breast Cancer

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Abstract
Representative gating for flow cytometry analyzing percent BrdU uptake relative to PI in MCF-7 cells analyzed via flow cytometry All treatments were performed in charcoal stripped media after 48 hours of estrogen deprivation in charcoal stripped media followed by 36 hours of Lovastatin (10 µM) to synchronize cell cycles. Gating for BrdU is shown for both WT and Y537S cells untreated or treated with 0.5 mM Hydroxyurea (HU).