Photoredox-Catalyzed Radical Cascade Cyclization of N -Cyanamide Alkenes with N -Aminopyridinium Salts: Modular Synthesis of Polycyclic Quinazolinones

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Abstract
A photoredox-catalyzed strategy enables the dual N-centered radical cascade cyclization of N-cyanamide olefins with N-sulfon/benzoylaminopyridinium salts, efficiently constructing 48 amide-decorated 2,3-fused polycyclic quinazolinones in yields of up to 86%. This metal- and base-free protocol exhibits mild reaction conditions. Moreover, they are compatible with a variety of functional groups and can accommodate a range of substrate structures. Notably, the method's practical utility is highlighted by successful gram-scale implementation and facile downstream derivatization.
Funding Information
  • National Natural Science Foundation of China (21172200)

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