Yusheng Wu

A visible light–induced cascade cyclization strategy of unactivated alkenes with N ‐aminopyridinium salts was explored to build a series of tetrahydropyridazines and dihydropyrazoles in yield of 17% –82% with 41 examples. This protocol features mild reaction conditions (irradiation with a 10 W blue LED at room temperature) and can simultaneously form two chemical bonds, offering a rapid and concise approach to five‐ or six‐membered heterocyclic frameworks. The scalability of this method and the feasibility of further transformations have also been demonstrated, highlighting its potential for applications in the industrial and pharmaceutical sectors.

Thermal [3+2] cyclization in aqueous media for the synthesis of thieno/selenopheno[2,3- b ]quinoline derivatives.

A simple and metal-free photoinduced radical trifluoromethylation/cyclization reaction of alkynes with readily preparable and air-stable trifluoromethyl thianthrenium triflate (TT-CF ₃ ⁺ OTf ⁻ ) as the trifluoromethyl source has been developed.

A photoredox-catalyzed strategy enables the dual N-centered radical cascade cyclization of N-cyanamide olefins with N-sulfon/benzoylaminopyridinium salts, efficiently constructing 48 amide-decorated 2,3-fused polycyclic quinazolinones in yields of up to 86%. This metal- and base-free protocol exhibits mild reaction conditions. Moreover, they are compatible with a variety of functional groups and can accommodate a range of substrate structures. Notably, the method's practical utility is highlighted by successful gram-scale implementation and facile downstream derivatization.

A photocatalytic three-component cyclization reaction of 2-vinylarylamines with CF₃SO₂Na and arylaldehydes to access 3-(2,2,2-trifluoroethyl)-3H-indoles was developed.

This article reports a synthesis of hydroxyacylation substituted pyrrolidinone derivatives through regioselective tandem cyclization reaction of 1,5-dienes with phenylglyoxylic acid and water under visible light irradiation. This protocol features mild reaction conditions using a 12 W blue LED as the light source and CH₃CN/H₂O (1 : 1) as the solvent at room temperature. Additionally, a range of pyrrolidinones bearing two chiral centers can be easily accessed by this strategy, with the yields up to 78%, which makes the protocol more appealing toward natural product and medicinal chemistry development.

A mild silver-mediated cascade trifluoromethylthiolation/cyclization of unactivated alkenes with readily available AgSCF₃ as the trifluoromethylthiolating reagent has been explored.

Reported herein is a practical, economical, and efficient construction of 3-alkylated quinoxalin-2(1H)-ones with alkyl carboxylic acids and alkyl iodides by quinoxalin-2(1H)-one excitation and cobaloxime catalysis. Primary, secondary, and tertiary alkyl iodides and carboxylic acids all could be efficiently transferred into target products with excellent functional group tolerance. Mechanism studies reveal that the quinoxalin-2(1H)-one derivatives could be directly excited and yield alkyl carbon radicals from alkyl carboxylic acids and alkyl iodides with the aid of the cobaloxime complex.

An iron‐catalyzed direct C3−H radical trifluoromethylthiolation of quinoxalin‐2(1H)‐ones has been developed. This protocol uses earth‐abundant FeSO₄ ⋅ 7H₂O as the catalyst, and AgSCF₃ as the trifluoromethylthiolating reagent to provide various SCF₃‐containing quinoxalin‐2(1H)‐one derivatives in 26–88% yields. Preliminary mechanistic investigations indicate that the reaction proceeds through a radical pathway.

A visible‐light induced multicomponent reaction of aromatic aldehydes, amines and sodium difluoromethanesulfinate for the synthesis of fluorinated secondary amines has been investigated. The protocol affords a convenient pathway for the introduction of difluoromethyl group into imines, which generated in situ by the reaction of aldehydes and amines. A diverse range of fluorinated secondary amines were synthesized in 43%–79% yields under room temperature. In addition, a plausible mechanism was proposed based on several control experiments.