Talarodrides A–F, Nonadrides from the Antarctic Sponge-Derived Fungus Talaromyces sp. HDN1820200

Authors:
Publisher website
Google Scholar
Abstract
Six new nonadride derivatives, named talarodrides A–F (1–6), were isolated from the Antarctic sponge-derived fungus Talaromyces sp. HDN1820200. All structures including the absolute configurations were deduced by extensive spectroscopic analysis and computational ECD calculations. Compounds 1–4 share a rare caged bicyclo[4.3.1]-deca-1,6-diene with a bridgehead olefin and maleic anhydride core skeleton, while compounds 5 and 6 possess the first case of a naturally occurring 5/7/6 methanocyclonona[c]furan skeleton. Talarodride A (1) and talarodride B (2) showed selective inhibitory effects against Proteus mirabilis and Vibrio parahemolyticus with MICs of 3.13–12.5 μM.
Funding Information
  • Ministry of Science and Technology of the People's Republic of China (2018YFC1406705, 2018ZX09735004)
  • Shandong Province (2019KJM004, tsqn201812021)
  • Central University Basic Research Fund of China (201941001)
  • National Natural Science Foundation of China (41876216)
  • Natural Science Foundation of Shandong Province (ZR2019ZD18)
  • Marine S&T Fund of Shandong Province for Qingdao Pilot National Laboratory for Marine Science and Technology (2018SDKJ0401-2)

This publication has 22 references indexed in Scilit: