On the Chemistry of Latrunculins A and B

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Abstract
The chemical behavior of latrunculins A (1) and B (2) (Lat A and B) under a variety of reaction conditions is described. The combination of the macrolide, the THP‐lactol, and the 2‐thiazolidinone rings was found to result in interesting unpredicted chemical transformations. The structures of two new Lats, 6,7‐epoxy‐Lat A (3) and Lat M (4) isolated from Latrunculia magnifica are discussed.

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