On the Chemistry of Latrunculins A and B
Authors:
- 13 December 1989
- journal article
- research article
- Published by Wiley in European Journal of Organic Chemistry
- Vol. 1989 (12) , 1171-1188
Abstract
The chemical behavior of latrunculins A (1) and B (2) (Lat A and B) under a variety of reaction conditions is described. The combination of the macrolide, the THP‐lactol, and the 2‐thiazolidinone rings was found to result in interesting unpredicted chemical transformations. The structures of two new Lats, 6,7‐epoxy‐Lat A (3) and Lat M (4) isolated from Latrunculia magnifica are discussed.Keywords
This publication has 13 references indexed in Scilit:
- Latrunculins—novel marine macrolides that disrupt microfilament organization and affect cell growth: I. Comparison with cytochalasin DCell Motility, 1989
- Inhibition of actin polymerization by latrunculin AFEBS Letters, 1987
- Rearrangement and opening of the macrolide of latrunculin BTetrahedron Letters, 1987
- Latrunculin inhibits the microfilament-mediated processes during fertilization, cleavage and early development in sea urchins and miceExperimental Cell Research, 1986
- Synthetic studies related to latrunculin. Synthesis of tetrahydropyranylthiazolidin-2-one systemsTetrahedron Letters, 1986
- Marine toxins of Latrunculia magnificaThe Journal of Organic Chemistry, 1983
- Latrunculins: Novel Marine Toxins That Disrupt Microfilament Organization in Cultured CellsScience, 1983
- The first synthesis of a ‘C-disaccharide’Journal of the Chemical Society, Chemical Communications, 1983
- Latrunculin, a new 2-thiazolidinone macrolide from the marine spongeTetrahedron Letters, 1980
- Chemoselectivity in the reduction of aldehydes and ketones with amine boranesTetrahedron Letters, 1980