Neuroengineering frontiers: bioengineering and technological interventions for brain disorders
Open Access
- 30 April 2026
- journal article
- review article
- Published by Springer Nature in The Egyptian Journal of Neurology, Psychiatry and Neurosurgery
- Vol. 62 (1) , 103
Abstract
Introduction: Brain disorders, including Parkinson’s disease, epilepsy, traumatic brain injury, and psychiatric illnesses, continue to pose substantial clinical and societal burdens. Traditional treatment approaches are often limited by poor targeting efficiency and the complexity of neural networks. Neuroengineering combines principles of engineering, materials science, and neuroscience to develop innovative tools capable of monitoring and modulating brain activity. Advances in neural interfaces, neurostimulation technologies, and bioengineered therapeutic systems are enabling more precise and minimally invasive treatment strategies, offering new possibilities for restoring neurological function and improving patient outcomes. Short summary: Brain disorders represent one of the greatest challenges in modern medicine, demanding innovative approaches that integrate neuroscience, engineering, and technology. Neuroengineering has emerged as a transformative discipline that bridges these domains, offering new strategies for diagnosis, monitoring, and therapeutic intervention. This review discusses recent advances in neuroengineering technologies, including neural interfaces, neurostimulation systems, nanotechnology-based therapeutics, and tissue engineering approaches supported by artificial intelligence for precision brain disorder management. Conclusion: Neuroengineering represents a rapidly evolving field with the potential to transform brain healthcare through innovative diagnostic and therapeutic technologies. Continued interdisciplinary collaboration and technological refinement are essential to overcome translational challenges and achieve widespread clinical implementation.Keywords
This publication has 120 references indexed in Scilit:
- Insights into pathophysiology, biomarkers, and therapeutics in tauopathies: Proceedings of the Tau2024 Global ConferenceAlzheimer's & Dementia, 2025
- The Landscape of Biomimetic Nanovesicles in Brain DiseasesAdvanced Materials, 2023
- Artificial intelligence for diagnostic and prognostic neuroimaging in dementia: A systematic reviewAlzheimer's & Dementia, 2023
- AdvancedMRTechniques for Preoperative Glioma Characterization: Part 2Journal of Magnetic Resonance Imaging, 2023
- Advanced MR Techniques for Preoperative Glioma Characterization: Part 1Journal of Magnetic Resonance Imaging, 2023
- Engineered Microparticles for Treatment of Murine Brain Metastasis by Reprograming Tumor Microenvironment and Inhibiting MAPK PathwayAdvanced Science, 2023
- Toward the next generation of vascularized human neural organoidsMedicinal Research Reviews, 2022
- Dyconnmap: Dynamic connectome mapping—A neuroimaging python moduleHuman Brain Mapping, 2021
- Innovations in deep brain stimulation methodologyMovement Disorders, 2016
- Technological aids for the rehabilitation of memory and executive functioning in children and adolescents with acquired brain injuryCochrane Database of Systematic Reviews, 2016