Association between heart rate fragmentation and kidney function decline in MESA: evidence consistent with parasympathetic degradation

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Abstract
This study identifies reduced cardiac parasympathetic activity, measured by heart rate fragmentation (HRF), as a potential contributor to accelerated renal function decline in a community-based population. The findings suggest a mechanistic link between vagal dysfunction and kidney deterioration. From a translational perspective, the results support the utility of HRF—a noninvasive, repeatable measure—for renal disease risk stratification and monitoring of autonomic-targeted interventions.
Funding Information
  • HHS | NIH | National Heart, Lung, and Blood Institute (R01HL144510)
  • HHS | NIH | National Institute of Biomedical Imaging and Bioengineering (R01EB030362)
  • HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (K26DK138333)
  • HHS | NIH | National Heart, Lung, and Blood Institute (75N92020D00001)
  • HHS | NIH | National Heart, Lung, and Blood Institute (N01-HC-95161)
  • HHS | NIH | National Heart, Lung, and Blood Institute (N01-HC-95164)
  • HHS | NIH | National Heart, Lung, and Blood Institute (N01-HC-95169)
  • HHS | NIH | National Center for Advancing Translational Sciences (UL1-TR-000040)
  • HHS | NIH | National Heart, Lung, and Blood Institute (R01HL098433)
  • HHS | National Institutes of Health (5R01AG070867)

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