Organocatalytic asymmetric Friedel–Crafts alkylation/cascade reactions of naphthols and nitroolefins
- 4 May 2007
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 22,p. 2228-2230
Abstract
The asymmetric Michael-type Friedel–Crafts reaction of naphthols and nitroolefins promoted by bifunctional thiourea–tertiary amine organocatalysts (up to 95% ee) was investigated; on simply extending the reaction time further cascade reactions could occur to generate enantiopure dimeric tricyclic 1,2-dihydronaphtho[2,1-b]furanyl-2-hydroxylamine derivatives.Keywords
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