Synthesis and characterization of poly(ε‐caprolactone)‐containing amino acid‐based poly(ether ester amide)s

Authors:
Publisher website
Google Scholar
Abstract
A new family of biodegradable amino acid‐based poly(ether ester amide)s (AA‐PEEAs) consisting of three building blocks [poly(ε‐caprolactone) (PCL), L‐phenylalanine (Phe), and aliphatic acid dichloride] were synthesized by a solution polycondensation. Using DMA as the solvent, these PCL‐containing Phe‐PEEA polymers were obtained with fair to very good yields with weight average molecular weight (Mw) ranging from 6.9 kg/mol to 31.0 kg/mol, depending on the original molecular weight of PCL. The chemical structures of the PCL‐containing Phe‐PEEA polymers were confirmed by IR and NMR spectra. These PCL‐containing Phe‐PEEAs had lower Tg than most of the oligoethylene glycol (OEG) based AA‐PEEAs due to the more molecular flexibility of the PCL block in the backbones, but had higher Tg than non‐amino acid based PEEA. The solubility of the PCL‐containing Phe‐PEEA polymers in a wide range of common organic solvents, such as THF and chloroform, was significantly improved when comparing with aliphatic diol based poly(ester amide)s and OEG based AA‐PEEAs. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012

This publication has 23 references indexed in Scilit: