Metal-free C(sp 2 )–H trifluoromethylation and perfluoroalkylation of enamines via aryl radical-mediated halogen atom transfer
- 27 May 2026
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Organic Chemistry Frontiers
- Vol. 13 (14) , 4374-4380
Abstract
An efficient β-trifluoromethylation and perfluoroalkylation of enamide derivatives has been achieved under mild, transition metal-free conditions without requiring oxidants or photocatalysts.Keywords
Funding Information
- National Natural Science Foundation of China (22501035)
This publication has 48 references indexed in Scilit:
- Halogen Atom Transfer Enabled Radical Fluoroalkyl‐Thiolation of Unactivated AlkenesAdvanced Synthesis & Catalysis, 2025
- Photocatalytic Regioselective Tandem Cyclization Protocol to Trifluoromethylated PyrrolidonesEuropean Journal of Organic Chemistry, 2024
- Electrochemical Trifluoromethylalkoxylation of Endocyclic Enamides in Batch and FlowAdvanced Synthesis & Catalysis, 2024
- Three‐Component Reactions of 2,2,2‐Trifluoroethyl Ketones, Aryl Azides and Aqueous Ammonia for the Synthesis of 4‐Cyano‐1,2,3‐triazolesEuropean Journal of Organic Chemistry, 2023
- Electrochemically Induced Regio‐ and Stereoselective (E)‐β‐C(sp2)−H Trifluoromethylation and Arylsulfonylation of EnamidesAdvanced Synthesis & Catalysis, 2022
- Copper‐Catalyzed Difluoromethylation of Alkyl Iodides Enabled by Aryl Radical Activation of Carbon–Iodine BondsAngewandte Chemie International Edition, 2021
- Visible-light-promoted and photocatalyst-free trifluoromethylation of enamidesScience China Chemistry, 2015
- Iron‐Catalyzed Trifluoromethylation of EnamideChemistry – A European Journal, 2015
- A General Synthesis of Fluoroalkylated Alkenes by Palladium‐Catalyzed Heck‐Type Reaction of Fluoroalkyl BromidesAngewandte Chemie International Edition, 2014
- Direct C-H Functionalization of Enamides and Enecarbamates by Using Visible‐Light Photoredox CatalysisChemistry – A European Journal, 2012