Asymmetric Arylation of Diazoesters with Anisoles Enabled by Cooperative Gold and Phosphoric Acid Catalysis
- 8 April 2022
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 24 (15) , 2809-2814
Abstract
An enantioselective insertion of a carbene into the Csp2–H bond of anisole derivatives has been accomplished using an achiral gold complex and a chiral phosphoric acid as the catalytic system, providing a novel protocol for the synthesis of chiral α,α-diaryl acetates. Density functional theory calculations reveal the reactivity and the origin of the enantioselectivity of this reaction.Keywords
Funding Information
- National Natural Science Foundation of China (21933004, 21971026, 22171028)
- Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology, Changzhou University (BM2012110)
- Guangdong Province (2020B010188001)
- Shenzhen San-Ming Project (SZSM201809085)
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