Chiral 1,1-diaryl compounds as important pharmacophores
- 10 May 2013
- journal article
- review article
- Published by Royal Society of Chemistry (RSC) in MedChemComm
- Vol. 4 (6) , 893-907
Abstract
Compounds containing a 1,1-diaryl motif are numerous, and compounds of this type have found use as catalysts and molecular building blocks, however, this review focusses solely on chiral compounds, wherein the two aromatic rings attached to a central carbon are not identical, and highlights their use and importance as drugs and biologically active molecules.Keywords
This publication has 115 references indexed in Scilit:
- Catalytic Asymmetric Synthesis of Mixed 3,3′‐Bisindoles and Their Evaluation as Wnt Signaling InhibitorsAngewandte Chemie International Edition, 2013
- Synthesis and evaluation of human phosphodiesterases (PDE) 5 inhibitor analogs as trypanosomal PDE inhibitors. Part 2. Tadalafil analogsBioorganic & Medicinal Chemistry Letters, 2012
- Diarylketone Ketoreductase Screen and Synthesis Demonstration to Access mGlu2 Receptor PotentiatorsOrganic Process Research & Development, 2011
- Synthesis and Evaluation of Indatraline‐Based Inhibitors for Trypanothione ReductaseChemMedChem, 2010
- Structure−Activity Relationships for a Novel Series of Citalopram (1-(3-(Dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile) Analogues at Monoamine TransportersJournal of Medicinal Chemistry, 2010
- Isoquinoline-based analogs of the cancer drug clinical candidate tipifarnib as anti-Trypanosoma cruzi agentsBioorganic & Medicinal Chemistry Letters, 2009
- Practical Catalytic Asymmetric Synthesis of Diaryl-, Aryl Heteroaryl-, and DiheteroarylmethanolsJournal of the American Chemical Society, 2009
- Fatty acid amide hydrolase inhibitors. Surprising selectivity of chiral azetidine ureasBioorganic & Medicinal Chemistry Letters, 2009
- Combining 4-Aminoquinoline- and Clotrimazole-Based Pharmacophores toward Innovative and Potent Hybrid AntimalarialsJournal of Medicinal Chemistry, 2008
- Synthesis and Anticholinergic Activity of the Four Stereoisomers of 4-(Dimethylamino)-2-phenyl-2-(2-pyridyl)pentanamideJournal of Medicinal Chemistry, 1994