Efficient one-pot synthesis of 3,7-disubstituted 1,6-naphthyridin-2(1H)-ones through regioselective palladium-catalyzed cross-coupling and SNAr reactions
Authors:
- David MontoirDMDavid Montoir
- Alain TonnerreATAlain Tonnerre
- Muriel DuflosMDMuriel Duflos
- Marc-Antoine BazinMarc-Antoine Bazin
- 1 May 2015
- journal article
- Published by Elsevier in Tetrahedron
- Vol. 71 (21) , 3303-3313
Abstract
No abstract availableKeywords
This publication has 23 references indexed in Scilit:
- Structure Guided Lead Generation for M. tuberculosis Thymidylate Kinase (Mtb TMK): Discovery of 3-Cyanopyridone and 1,6-Naphthyridin-2-one as Potent InhibitorsJournal of Medicinal Chemistry, 2014
- Naphthyridinone (NTD) integrase inhibitors 4. Investigating N1 acetamide substituent effects with C3 amide groupsBioorganic & Medicinal Chemistry Letters, 2014
- Differential Functionalization of 1,6‐Naphthyridin‐2(1H)‐ones through Sequential One‐Pot Suzuki–Miyaura Cross‐CouplingsEuropean Journal of Organic Chemistry, 2014
- Pharmacological properties of AC-3933, a novel benzodiazepine receptor partial inverse agonistNeuroscience, 2014
- Cytotoxicity and Structure-activity Relationships of Naphthyridine Derivatives in Human Cervical Cancer, Leukemia, and Prostate CancerThe Korean Journal of Physiology & Pharmacology, 2013
- Discovery of 9-(6-Aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a Potent, Selective, and Orally Available Mammalian Target of Rapamycin (mTOR) Inhibitor for Treatment of CancerJournal of Medicinal Chemistry, 2011
- A Scalable Synthesis of a 1,7-Naphthyridine Derivative, a PDE-4 InhibitorOrganic Process Research & Development, 2010
- 1,8-Naphthyridines VII. New substituted 5-amino[1,2,4]triazolo[4,3-a][1,8]naphthyridine-6-carboxamides and their isosteric analogues, exhibiting notable anti-inflammatory and/or analgesic activities, but no acute gastrolesivityEuropean Journal of Medicinal Chemistry, 2008
- Different Modes of Action of Naphthyridones in Gram-Positive and Gram-Negative BacteriaAntimicrobial Agents and Chemotherapy, 2006
- Pharmacological Profile of a Novel Phosphodiesterase 4 Inhibitor, 4-(8-Benzo[1,2,5]oxadiazol-5-yl-[1,7]naphthyridin-6-yl)-benzoic Acid (NVP-ABE171), a 1,7-Naphthyridine Derivative, with Anti-Inflammatory ActivitiesThe Journal of Pharmacology and Experimental Therapeutics, 2002