Abstract
Objective To identify the perceptions of patients and healthcare professionals regarding patient participation in the safe administration of chemotherapy. Methods A qualitative, descriptive, and exploratory study conducted in three oncology outpatient clinics in the interior of the state of São Paulo, involving 30 patients and 16 healthcare professionals.. Data were collected through interviews and analyzed using thematic analysis, based on the World Health Organization’s “5 Moments for Medication Safety.” Results The study shows that, although patients and healthcare professionals value safety in chemotherapy, there are gaps in patients’ retention of information. Information about medications and side effects is conveyed but not always remembered. Moments such as the initiation and discontinuation of treatment are rarely mentioned, indicating gaps in the implementation of the World Health Organization’s “5 Moments for Medication Safety.” Conclusion Although healthcare professionals strive to provide guidance, many patients are unable to recall information about their medications due to the complexity of treatment and emotional distress. However, they feel safer when there is dialogue and practices that encourage participation, such as reviewing the prescription together. Strengthening this partnership is essential to prevent errors and promote safety in chemotherapy.

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