Copper-Catalyzed N-Methylation of Amides and O-Methylation of Carboxylic Acids by Using Peroxides as the Methylating Reagents
- 21 June 2013
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 15 (13) , 3326-3329
Abstract
The copper-catalyzed N-methylation of amides and O-methylation of carboxylic acids by using peroxides as the methylating reagent are described. Various amides and carboxylic acids were methylated affording N-substituted amides and esters. Tentative mechanistic studies suggest that this reaction is likely to involve a radical process.Keywords
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