Absence of mgrB Alleviates Negative Growth Effects of Colistin Resistance in Enterobacter cloacae

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Abstract
Colistin is an important last-line antibiotic to treat highly resistant Enterobacter infections. Resistance to colistin has emerged among clinical isolates but has been associated with a significant growth defect. Here, we describe a clinical Enterobacter isolate with a deletion of mgrB, a regulator of colistin resistance, leading to high-level resistance in the absence of a growth defect. The identification of a path to resistance unrestrained by growth defects suggests colistin resistance could become more common in Enterobacter.
Funding Information
  • National Institutes of Health (AI141883)
  • Burroughs Wellcome Fund (David S. Weiss)

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