MUC5ACExpression in Human Middle Ear Epithelium of Patients With Otitis Media
Open Access
- 16 August 2010
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA Otolaryngology–Head & Neck Surgery
- Vol. 136 (8) , 819-824
Abstract
Although otitis media (OM) is a prevalent condition responsible for conductive hearing loss in the pediatric population and substantial health care costs totaling several billion dollars annually in the United States, little is still known about the molecular pathophysiologic characteristics of this condition. Increased production and secretion of mucins in middle ear epithelium (MEE), in response to the inflammatory events that occur in OM, provides both protection to the middle ear (ME) and contributes to ME disease that can subsequently occur. Mucins, such as mucin gene 5AC (MUC5AC), participate in protecting the underlying MEE from pathogen invasion and pathogen damage and assist with pathogen clearance. However, overproduction of these same mucins can lead to increased viscosity of ME fluids, limiting mucociliary clearance in the ME, and eventual accumulation within the ME, leading to hearing loss.1Keywords
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