Enantioselective Synthesis of C2-Symmetric Spirobilactams via Pd-Catalyzed Intramolecular Double N-Arylation
Authors:
- 2 March 2009
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 11 (7) , 1483-1486
Abstract
A Pd/BINAP-complex-catalyzed enantioselective intramolecular double N-arylation of malonamides bearing 2-bromoarylmethyl groups furnished C2-symmetric spirobi(3,4-dihydro-2-quinolone) derivatives in up to 70% ee.Keywords
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