Combined dandelion extract and all-trans retinoic acid induces cytotoxicity in human breast cancer cells
Open Access
- 12 September 2023
- journal article
- research article
- Published by Springer Nature in Scientific Reports
- Vol. 13 (1) , 1-12
Abstract
Breast cancer is one of the most prevalent and deadly cancers among women worldwide. Recently, natural compounds have been widely used for the treatment of breast cancer. Present study evaluated antiproliferative and anti-metastasis activities of two natural compounds of dandelion and all-trans-retinoic acid (ATRA) in human MCF-7 and MDA-MB231 breast cancer cells. We also evaluated the expression of MMP-2, MMP-9, IL-1β, p53, NM23 and KAI1 genes. Data showed a clear additive cytotoxic effect in concentrations of 40 μM ATRA with 1.5 and 4 mg/ml of dandelion extract in MCF-7 and MDA-MB231 cells, respectively. In both cell lines, compared with the untreated cells, the expression levels of MMP-9 and IL-1β were significantly decreased while p53 and KAI1 expression levels were increased. Besides, MMP-2 and NM23 had different expressions in the two studied cell lines. In conclusion, dandelion/ATRA co-treatment, in addition to having strong cytotoxic effects, has putative effects on the expression of anti-metastatic genes in both breast cancer cells.Keywords
This publication has 87 references indexed in Scilit:
- Prolyl-4-hydroxylase α subunit 2 promotes breast cancer progression and metastasis by regulating collagen depositionBMC Cancer, 2014
- Inhibition of matrix metalloproteinases expression in human dental pulp cells by all-trans retinoic acidInternational Journal of Oral Science, 2013
- The potential mechanism for the different expressions of gelatinases induced by all-trans retinoic acid in different cellsJournal of Receptors and Signal Transduction, 2012
- PKD2 mediates multi-drug resistance in breast cancer cells through modulation of P-glycoprotein expressionCancer Letters, 2011
- Vitamin A Enhances Antitumor Effect of a Green Tea Polyphenol on Melanoma by Upregulating the Polyphenol Sensing Molecule 67-kDa Laminin ReceptorPLOS ONE, 2010
- KAI1/CD82, a tumor metastasis suppressorCancer Letters, 2006
- Acquired chemoresistance in pancreatic carcinoma cells: induced secretion of IL-1β and NO lead to inactivation of caspasesOncogene, 2006
- Caspase 9 is required for p53-dependent apoptosis and chemosensitivity in a human ovarian cancer cell lineOncogene, 2002
- Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodMethods, 2001
- Coumarins, Caffeoyltartaric Acids and their Artifactual Methyl Esters fromTaraxacum officinaleLeavesPlanta Medica, 1997