α-N-Heteroarylation and α-Azidation of Ketones via Enolonium Species
- 30 January 2018
- journal article
- research article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 83 (4) , 2442-2447
Abstract
Enolonium Species, resulting from the umpolung of ketone enolates by Koser’s hypervalent iodine reagents activated by boron trifluoride, react with a variety of nitrogen heterocycles to form α-aminated ketones. The reactions are mild and complete in 4-5 hours. Additionally, α-azidation of the enolonium species takes place using trimethylsilyl azide as a convenient source of azide nucleophile.Keywords
Funding Information
- Israel Science Foundation (1914/15)
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