A quadratic isothermal amplification fluorescent biosensor without intermediate purification for ultrasensitive detection of circulating tumor DNA

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Abstract
A quadratic amplification fluorescence biosensor constructed by combining nicking enzyme mediated amplification (NEMA) and catalytic hairpin assembly (CHA) reactions. After quadratic amplification, this biosensor achieved nearly 107-fold, enabling it to detect ctDNA with ultra-sensitivity.
Funding Information
  • National Natural Science Foundation of China (81872415)

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