Iridium( iii )–Cp*-(imidazo[4,5- f ][1,10]phenanthrolin-2-yl)phenol analogues as hypoxia active, GSH-resistant cancer cytoselective and mitochondria-targeting cancer stem cell therapeutic agents
Authors:
- Binoy KarBKBinoy Kar
- Shanooja ShanavasSSShanooja Shanavas
- Utpal DasUDUtpal Das
- Nilmadhab RoyNRNilmadhab Roy
- Sudhindra PeteSPSudhindra Pete
- Ajay Sharma SASAjay Sharma S
- Sourav DeSDSourav De
- Ashok Kumar S KAKAshok Kumar S K
- Seshu VardhanSVSeshu Vardhan
- Suban K. SahooSSSuban K. Sahoo
- Debashis PandaDPDebashis Panda
- 3 March 2022
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Dalton Transactions
- Vol. 51 (14) , 5494-5514
Abstract
GSH-resistant, hypoxia active iridium( iii )–Cp*-(imidazo[4,5- f ][1,10]phenanthrolin-2-yl)phenol complexes were developed as highly cytoselective anticancer agents and mitochondria-targeting CSC therapeutic agents.Keywords
Funding Information
- Department of Science and Technology, Ministry of Science and Technology, India (EMR/2017/000816)
- VIT University
- Anusandhan National Research Foundation (CRG/2021/002267)
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