Ajay Sharma S.

L-Altruronic acid-based glycoconjugates demonstrate excellent preliminary efficacy as antigens for Enterococcus faecium vaccine development; however, progress has been limited by the poor accessibility of l-altruronic acid. We report here on a concise preparation of a donor-functionalized derivative of l-altruronic acid via a fluorine-directed C-5 epimerization. DFT calculations also reveal how the stereoselectivity of epimerization is influenced by stabilizing effects in the intermediate carbohydrate radicals.

Our laboratory has previously reported on a contemporary Ferrier photobromination which circumvents critical limitations of the original reaction. The new conditions provide highly efficient and scalable routes to O-acetylated 5-C-bromosugars but cannot be used to access O-benzoylated derivatives. Herein, we show that the scope of the Ferrier photobromination can be expanded to encompass important O-benzoylated carbohydrates by a simple but effective modification of the reaction conditions. This advance importantly paves the way for improved syntheses of glycosidase inhibitors and rare L-hexoses.

In this review, rhenium-based complexes are highlighted as promising cancer theranostics, which are endowed with the ability to detect and annihilate cancer cells in the body.

GSH-resistant, hypoxia active iridium( iii )–Cp*-(imidazo[4,5- f ][1,10]phenanthrolin-2-yl)phenol complexes were developed as highly cytoselective anticancer agents and mitochondria-targeting CSC therapeutic agents.