Protein-linked RNA of poliovirus is competent to form an initiation complex of translation in vitro
Authors:
- Fred GoliniFGFred Golini
- Bert L. SemlerBSBert L. Semler
- Andrew J. DornerADAndrew J. Dorner
- Eckard WimmerEWEckard Wimmer
- 1 October 1980
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 287 (5783) , 600-603
Abstract
Poliovirus RNA that was labeled with 125I in the 5''-terminal protein (VPg) was found competent to form an initiation complex of translation in a cell-free reticulocyte lysate. In conditions of ribosome binding, no cleavage occurred between VPg and RNA. Removal of VPg from poliovirus RNA is not a prerequisite for this RNA to initiate translation in vitro.Keywords
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