Bioactive prenylated phenyl derivatives derived from marine natural products: novel scaffolds for the design of BACE inhibitors
- 9 January 2014
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in MedChemComm
- Vol. 5 (4) , 474-488
Abstract
Bioassay guided-fractionation of active extracts from the sponge Sarcotragus sp. led to the isolation biochemical characterization and development of a chemistry program of bioactive prenylated phenyl derivatives.Keywords
This publication has 27 references indexed in Scilit:
- Developing β‐secretase inhibitors for treatment of Alzheimer’s diseaseJournal of Neurochemistry, 2011
- The β-Secretase Enzyme BACE in Health and Alzheimer's Disease: Regulation, Cell Biology, Function, and Therapeutic PotentialThe Journal of Neuroscience, 2009
- Natural products and drug discoveryEMBO Reports, 2009
- Alternative pathways for production of β-amyloid peptides of Alzheimer's diseaseBiological Chemistry, 2008
- β-Secretase as a Therapeutic Target for Alzheimer's DiseaseNeurotherapeutics, 2008
- Synthesis of Platensimycin Analogues and Their Antibiotic PotencyArchiv der Pharmazie, 2008
- Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptideNature Reviews Molecular Cell Biology, 2007
- Synthesis and antimycobacterial activity of agelasine E and analogsOrganic & Biomolecular Chemistry, 2005
- Series Introduction: Alzheimer’s disease: perspectives for the new millenniumJournal of Clinical Investigation, 1999
- A New Tetraprenylhydroquinone Derivative with an Acetic Acid Unit from the Marine Sponge Ircinia muscarumJournal of Natural Products, 1996