Tau levels in platelets isolated from Huntington’s disease patients serve as a biomarker of disease severity

Authors:
Open Access
Publisher website
Google Scholar
Abstract
Tau is a microtubule protein that is known to be hyperphosphorylated and to aggregate in several chronic neurodegenerative disorders. In many cases, in particular in Alzheimer’s disease, the degree of tau pathology has been demonstrated to correlate with cognitive deficits and/or decline. In Huntington’s disease (HD), a dominantly inherited neurodegenerative disorder, both cognitive impairments and abnormal tau expression have been reported to occur, along with the accumulation of the mutant huntingtin protein. In this respect, tau has been shown to be present in the cerebrospinal fluid of individuals with HD and to increase with disease progression. However, how this relates to changes in tau found in the periphery is largely unknown. In this study, we collected blood samples from patients with HD and isolated multiple blood components including plasma, platelets, and peripheral blood mononuclear cells to measure their tau levels and subsequently correlate these to cognitive impairments and disease stage. Our results suggest that the amount of tau, particularly N-terminal tau (NTA-tau) and total tau (t-tau), is elevated in all assayed blood components and that the quantity of tau within platelets, specifically, is strongly correlated with disease severity.
Funding Information
  • Canadian Institutes of Health Research
  • Huntington's Disease Society of America
  • Wellcome Trust
  • Medical Research Council
  • NIHR Cambridge Biomedical Research Centre
  • Vetenskapsrådet (2017-00915, 2022-00732, ALFGBG-715986, ALFGBG-965240, 2023-00356, 2022-01018, 2019-02397, ALFGBG-71320)
  • Alzheimerfonden (AF-930351, AF-939721, AF-968270)
  • Hjärnfonden (FO2017-0243, ALZ2022-0006, FO2022-0270)
  • EU Joint Programme – Neurodegenerative Disease Research (JPND2019-466-236, JPND2021-00694)
  • Alzheimer's Association (ZEN-21-848495, SG-23-1038904 QC, ADSF-21-831376-C, ADSF-21-831381-C, ADSF-21-831377-C, ADSF-24-1284328-C)
  • European Union’s Horizon Europe research and innovation programme (101053962)
  • Alzheimer's Drug Discovery Foundation (201809-2016862)
  • European Partnership on Metrology (#22HLT07)
  • HORIZON EUROPE Marie Sklodowska-Curie Actions (860197)
  • UK Dementia Research Institute (UKDRI-1003)

This publication has 65 references indexed in Scilit: