Synthesis of PF-6870961, a major hydroxy metabolite of the novel ghrelin receptor inverse agonist PF-5190457
Open Access
- 1 November 2021
- journal article
- research article
- Published by Elsevier in Bioorganic & Medicinal Chemistry
- Vol. 50, 116465
Abstract
No abstract availableKeywords
This publication has 8 references indexed in Scilit:
- Endocrine effects of the novel ghrelin receptor inverse agonist PF-5190457: Results from a placebo-controlled human laboratory alcohol co-administration study in heavy drinkersNeuropharmacology, 2020
- Development and validation of an assay for a novel ghrelin receptor inverse agonist PF-5190457 and its major hydroxy metabolite (PF-6870961) by LC-MS/MS in human plasmaJournal of Chromatography B, 2019
- Role of Molybdenum-Containing Enzymes in the Biotransformation of the Novel Ghrelin Receptor Inverse Agonist PF-5190457: A Reverse Translational Bed-to-Bench ApproachDrug Metabolism and Disposition, 2019
- Ghrelin: From a gut hormone to a potential therapeutic target for alcohol use disorderPhysiology & Behavior, 2019
- The novel ghrelin receptor inverse agonist PF-5190457 administered with alcohol: preclinical safety experiments and a phase 1b human laboratory studyMolecular Psychiatry, 2018
- The Role of the Ghrelin System in Drug Addiction2017
- Pharmacokinetics and pharmacodynamics of PF‐05190457: The first oral ghrelin receptor inverse agonist to be profiled in healthy subjectsBritish Journal of Clinical Pharmacology, 2016
- Discovery of PF-5190457, a Potent, Selective, and Orally Bioavailable Ghrelin Receptor Inverse Agonist Clinical CandidateACS Medicinal Chemistry Letters, 2014