Development and validation of an assay for a novel ghrelin receptor inverse agonist PF-5190457 and its major hydroxy metabolite (PF-6870961) by LC-MS/MS in human plasma
Authors:
- Rohitash JamwalRohitash Jamwal
- Lorenzo LeggioLLLorenzo Leggio
- Fatemeh AkhlaghiFAFatemeh Akhlaghi
- 1 November 2019
- journal article
- research article
- Published by Elsevier in Journal of Chromatography B
- Vol. 1130-1131, 121820
Abstract
No abstract availableKeywords
Funding Information
- National Center for Advancing Translational Sciences (UH2/UH3-TR000963)
- NIH (AA000218)
- Division of Intramural Clinical and Biological Research of the National Institute on Alcohol Abuse and Alcoholism
- Intramural Research Program of the National Institute on Drug Abuse
- NCATS (UH2/UH3-TR000963)
This publication has 32 references indexed in Scilit:
- Ghrelin Receptor (GHS-R1A) Antagonism Suppresses Both Alcohol Consumption and the Alcohol Deprivation Effect in Rats following Long-Term Voluntary Alcohol ConsumptionPLOS ONE, 2013
- Substituted azaquinazolinones as modulators of GHSr-1a for the treatment of type II diabetes and obesityBioorganic & Medicinal Chemistry Letters, 2012
- Development and validation of a sensitive, simple, and rapid method for simultaneous quantitation of atorvastatin and its acid and lactone metabolites by liquid chromatography-tandem mass spectrometry (LC-MS/MS)Analytical and Bioanalytical Chemistry, 2011
- Ghrelin Receptor Antagonism Decreases Alcohol Consumption and Activation of Perioculomotor Urocortin‐Containing NeuronsAlcohol, Clinical and Experimental Research, 2010
- Identification of piperazine-bisamide GHSR antagonists for the treatment of obesityBioorganic & Medicinal Chemistry Letters, 2010
- Confirmatory reanalysis of incurred bioanalytical samplesThe AAPS Journal, 2007
- Liquid chromatography–mass spectrometry/mass spectrometry method development for drug metabolism studies: Examining lipid matrix ionization effects in plasmaJournal of Chromatography B, 2006
- Matrix effects: the Achilles heel of quantitative high-performance liquid chromatography–electrospray–tandem mass spectrometryClinical Biochemistry, 2005
- Ghrelin, appetite, and gastric motility: the emerging role of the stomach as an endocrine organThe FASEB Journal, 2004
- Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilinGastroenterology, 2001