Scaling and democratising structure-based protein function prediction with metagenomic-deepFRI
Preprint
Abstract
High-quality protein structure models have become widely available, offering insights into protein function, yet they remain underutilized. Here, we introduce metagenomic-deepFRI, a framework incorporating structural templates into functional annotation pipelines at speeds comparable to sequence-alignment methods. Notably, structural features improved GO term prediction confidence and Information Content by up to 50%. Applied to metagenomic datasets, the framework achieves nearly 90% annotation coverage, enabling protein function inference without explicit orthology-based transfer.Keywords
Funding Information
- Ministry of Science and Higher Education of the Russian Federation (MEiN/2023/DIR/3796)
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