Piotr Kucharski
Piotr Kucharski has a total of 6 co-authors. Here are the top co-authors by number of shared publications:
- Filip Schymik
Sano Centre for Computational Medicine, Krakow, Poland
1 shared publication - Jakub W. Wojciechowski
Sano Centre for Computational Medicine, Krakow, Poland
1 shared publication - Lukasz Szydlowski
Sano Centre for Computational Personalised Medicine
1 shared publication - Paweł Szczerbiak
Sano Centre for Computational Medicine, Krakow, Poland
1 shared publication - Tomasz Kosciolek
Sano Centre for Computational Medicine
1 shared publication - Valentyn Bezshapkin
Institute of Microbiology and Swiss Institute of Bioinformatics, ETH Zürich, Zürich, Switzerland
1 shared publication
Latest Publications
- Open Access
Scaling and democratising structure-based protein function prediction with metagenomic-deepFRI
High-quality protein structure models have become widely available, offering insights into protein function, yet they remain underutilized. Here, we introduce metagenomic-deepFRI, a framework incorporating structural templates into functional annotation pipelines at speeds comparable to sequence-alignment methods. Notably, structural features improved GO term prediction confidence and Information Content by up to 50%. Applied to metagenomic datasets, the framework achieves nearly 90% annotation coverage, enabling protein function inference without explicit orthology-based transfer.
Open AccessScaling and democratising structure-based protein function prediction with metagenomic-deepFRI
High-quality protein structure models have become widely available, offering insights into protein function, yet they remain underutilized. Here, we introduce metagenomic-deepFRI, a framework incorporating structural templates into functional annotation pipelines at speeds comparable to sequence-alignment methods. Notably, structural features improved GO term prediction confidence and Information Content by up to 50%. Applied to metagenomic datasets, the framework achieves nearly 90% annotation coverage, enabling protein function inference without explicit orthology-based transfer.