Patterns of cell proliferation in gastrointestinal disease

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Abstract
Summary Recent analyses have revealed abnormalities in the renewal pattern of proliferating gastrointestinal cells. In polyps, villous adenomas, hyperplasia of mucosa, and in histologically normal tissue near these lesions, an abnormal location of proliferating cells was observed. The displaced zone of actively proliferating cells may be the earliest sign of hyperplastic activity and future polyp development. Abnormalities in the proliferative cell cycle of carcinoma cells and normal cells adjacent to a carcinoma were also found. In intestinalized atrophic gastric mucosa, rapid epithelial cell proliferation was seen. Inhibition of the proliferation of epithelial cells in gastric mucosa contributed to the development of experimental stress erosions. These findings point to alterations in biochemical events, within proliferating cells and possibly in the surrounding environment, that have specific roles in the causation of these diseases of the mucosa.