Investigation of Postmortem Functional Changes in Human Cerebral Arteries
Authors:
- Nobuyoshi KaitoNKNobuyoshi Kaito
- Toshiaki AbeTAToshiaki Abe
- Koichi TashibuKTKoichi Tashibu
- Hiroyasu NagashimaHNHiroyasu Nagashima
- Norio NakamuraNNNorio Nakamura
Open Access
- 1 March 1993
- journal article
- Published by SAGE Publications in Journal of Cerebral Blood Flow & Metabolism
- Vol. 13 (2) , 346-349
Abstract
This study demonstrated the time-dependent changes in postmortem responses of isolated human middle cerebral artery strips to vasodilators. The relaxation induced by prostaglandin (PG) I2or nitroglycerin remained stable for 24 h postmortem. In arterial strips precontracted with PGF2α, substance P and bradykinin both elicited relaxation that was almost completely abolished by removal of the endothelium. The endothelium-dependent response to both peptides was significantly degraded in strips obtained >12 h postmortem. These results indicate a selective functional or anatomical vulnerability of the vascular endothelium compared with that of the vasodilator mechanisms of the smooth muscle in the postmortem period. However, cerebral arteries isolated from human cadavers within 12 h postmortem should be adequate for studies of both smooth muscle and endothelial reactivity to vasodilators.Keywords
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