Synthesis, crystal structure, DNA binding, and DNA cleavage of a zinc complex containingN,N-bis(2-pyridylmethyl)amine
Authors:
- 14 July 2011
- journal article
- research article
- Published by Taylor & Francis in Journal of Coordination Chemistry
- Vol. 64 (14) , 2480-2488
Abstract
A water-soluble zinc complex, [Zn(bpea)Cl2] (1) (bpea = N,N-bis(2-pyridylmethyl)ethylamine), was prepared to serve as a nuclease mimic. The complex was characterized by X-ray, infrared, and UV spectroscopy. Interactions of the complex with calf thymus-DNA (ct-DNA) have been investigated by UV absorption and fluorescence spectroscopies; the mode of ct-DNA binding for 1 has been proposed. DNA cleavage activities by 1 were performed in the absence of external agents. The influences of different complex concentrations or reaction times on DNA cleavage were studied.Keywords
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